{"title":"Hedera Dx","description":null,"products":[{"product_id":"hedera-profiling-1-dna-tissue-test-panel-hp1-ffpe-t48-8tp126irm","title":"Hedera Profiling 1 DNA Tissue Test Panel (HP1 FFPE), 115-Gene NGS Tumor Profiling Kit, 48 Tests","description":"\u003cp\u003eHedera Profiling 1 (HP1 FFPE) is a 115-gene, hybrid-capture NGS panel for profiling the most common solid tumors from FFPE tissue DNA. A single DNA-only assay detects SNVs, Indels, CNVs, Fusions and MSI and covers all NCCN-guideline and ESCAT Level I genomic targets. 48 tests per kit, in a manual or an automation-ready format.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 115-gene panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across all tumor types in a single, DNA-only assay\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e Covers all NCCN-guideline and ESCAT Level I genomic targets in solid tumors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, it saves time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique fusions detection method on DNA:\u003c\/strong\u003e Cutting-edge proprietary technology to detect fusions with unmatched precision, enhancing the accuracy of complex variants detection\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd7d2a76dee08b683a9c4_HP1-workflow.png\" alt=\"Hedera Profiling 1 test panels sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e297.6 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e115 (79 full CDS)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e48 (6 captures of 8 samples)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series; Element Biosciences AVITI Systems\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecommended input amount\u003c\/td\u003e\n\u003ctd\u003emin 30 ng (50 ng recommended with \u0026gt;30% tumour content)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary enrichment method\u003c\/td\u003e\n\u003ctd\u003eHybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallows error correction and prevents index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Colorectal Cancer, Melanoma, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, APC, AR, ARAF, AR Enhancer, ARID1A, ARID1B, ATM, ATR, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CCNE1, CD274, CDK12, CDK4, CDKN2A, CDKN2B, CHEK1, CHEK2, CIC, CLDN18, CTNNB1, CUL3, DDR2, DICER1, EGFR, EPCAM, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, FANCA, FANCL, FAT1, FBXW7, FGFR1, FGFR2, FGFR2b, FGFR3, FGFR4, FOXL2, GNA11, GNAQ, GNAS, H3-3A, H3-3B, HIST1H3B, HIST1H3C, HIST1H3H, HRAS, IDH1, IDH2, KEAP1, KIT, KLF4, KRAS, MAP2K1, MAP2K2, MDM2, MEN1, MET, MLH1, MRE11, MSH2, MSH6, MTAP, MTOR, MYC, NBN, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDCD1, PDGFRA, PIK3CA, PIK3R1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, ROS1, SMAD4, SMARCA4, SMARCB1, SMO, STK11, TACSTD2, TERT Promoter, TP53, TRAF7, TSC1, TSC2, VHL\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eT48-8TP126IRM\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 1 DNA Tissue Test Panel (HP1 FFPE)\u003c\/td\u003e\n\u003ctd\u003eManual - 48 tests\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eT48-8TP126IRA\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 1 DNA Tissue Test Panel (HP1 FFPE)\u003c\/td\u003e\n\u003ctd\u003eAutomation - 48 tests\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures. This product is intended for laboratory research purposes only and is not intended for use in the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This product has not been cleared or approved by any regulatory authority for clinical or diagnostic use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Manual","offer_id":46798498005071,"sku":"T48-8TP126IRM","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Automation","offer_id":46798498037839,"sku":"T48-8TP126IRA","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/69dccb89f2c93665cb1fdb6d_HP1-box-1x.png?v=1789655454"},{"product_id":"hedera-profiling-1-ctdna-test-panel-hp1-ctdna-t24-4lp126irm","title":"Hedera Profiling 1 ctDNA Test Panel (HP1 ctDNA), 115-Gene NGS Liquid Biopsy Kit, 24 Tests","description":"\u003cp\u003eHedera Profiling 1 ctDNA (HP1 ctDNA) brings the 115-gene HP1 design to liquid biopsy: a hybrid-capture NGS panel that detects SNVs, Indels, CNVs, Fusions, MSI and tumor fraction from plasma cfDNA in one DNA-only assay, covering all NCCN-guideline and ESCAT Level I targets. 24 tests per kit.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 115-gene panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across all tumor types in a single, DNA-only assay\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e Covers all NCCN-guideline and ESCAT Level I genomic targets in solid tumors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, it saves time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique fusions detection method on DNA:\u003c\/strong\u003e Cutting-edge proprietary technology to detect fusions with unmatched precision, enhancing the accuracy of complex variants detection\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd7d2a76dee08b683a9c4_HP1-workflow.png\" alt=\"Hedera Profiling 1 test panels sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e297.6 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e115 (79 full CDS)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e24 (6 captures of 4 samples)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series; Element Biosciences AVITI Systems\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecommended input amount\u003c\/td\u003e\n\u003ctd\u003emin 10 ng (30 ng recommended)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary enrichment method\u003c\/td\u003e\n\u003ctd\u003eHybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallows error correction and prevents index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Colorectal Cancer, Melanoma, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, APC, AR, ARAF, AR Enhancer, ARID1A, ARID1B, ATM, ATR, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CCNE1, CD274, CDK12, CDK4, CDKN2A, CDKN2B, CHEK1, CHEK2, CIC, CLDN18, CTNNB1, CUL3, DDR2, DICER1, EGFR, EPCAM, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, FANCA, FANCL, FAT1, FBXW7, FGFR1, FGFR2, FGFR2b, FGFR3, FGFR4, FOXL2, GNA11, GNAQ, GNAS, H3-3A, H3-3B, HIST1H3B, HIST1H3C, HIST1H3H, HRAS, IDH1, IDH2, KEAP1, KIT, KLF4, KRAS, MAP2K1, MAP2K2, MDM2, MEN1, MET, MLH1, MRE11, MSH2, MSH6, MTAP, MTOR, MYC, NBN, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDCD1, PDGFRA, PIK3CA, PIK3R1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, ROS1, SMAD4, SMARCA4, SMARCB1, SMO, STK11, TACSTD2, TERT Promoter, TP53, TRAF7, TSC1, TSC2, VHL\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eT24-4LP126IRM\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 1 ctDNA Test Panel (HP1 ctDNA)\u003c\/td\u003e\n\u003ctd\u003e24 tests\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures. This product is intended for laboratory research purposes only and is not intended for use in the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This product has not been cleared or approved by any regulatory authority for clinical or diagnostic use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Default Title","offer_id":46798498070607,"sku":"T24-4LP126IRM","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/69dccb89f2c93665cb1fdb6d_HP1-box-1x.png?v=1789655454"},{"product_id":"hedera-profiling-2-ctdna-test-panel-hp2-t18-6lp223ir","title":"Hedera Profiling 2 ctDNA Test Panel (HP2), 32-Gene NGS Liquid Biopsy Kit, 18 Tests","description":"\u003cp\u003eHedera Profiling 2 (HP2) is a targeted 32-gene, hybrid-capture NGS liquid biopsy assay for profiling the most common solid tumors, including lung, breast and colorectal cancers. It detects SNVs, Indels, CNVs, Fusions and MSI from as little as 10 ng of plasma cfDNA and includes more than 80% of the ESCAT Level I genes. 18 tests per kit.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 32 gene-panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across \u0026gt; 10 most common tumor types in a single, DNA-only liquid biopsy assay\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e \u0026gt;80% of the ESCAT Level I genes are included in the panel including ESR1, METex14 and MSI status\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days, with as little as 10ng of cell-free DNA (30ng input recommended)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, save time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique fusions detection method on DNA:\u003c\/strong\u003e Cutting-edge proprietary technology to detect fusions in ctDNA with unmatched precision, enhancing the accuracy of complex variants detection in plasma samples\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd6e8c9b3a995429e94f5_HP2-workflow.png\" alt=\"Hedera Profiling 2 ctDNA test panel sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e90 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMultiplexing\u003c\/td\u003e\n\u003ctd\u003eup to 6 samples on a NextSeq 500\/550 instrument (MID Output flow cell)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSample size\u003c\/td\u003e\n\u003ctd\u003emin 5 mL plasma required (cfDNA BCT tubes by Streck recommended for blood collection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ecfDNA input\u003c\/td\u003e\n\u003ctd\u003emin 10ng cfDNA (30ng of cfDNA recommended)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary preparation method\u003c\/td\u003e\n\u003ctd\u003ehybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallowing error correction and preventing index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e18\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003ePerformance\u003c\/h2\u003e\u003cp\u003e32-gene NGS panel optimized to run samples across all solid tumor types recommended by ESMO for ctDNA testing including the vast majority of ESCAT Level I biomarkers published to date\u003c\/p\u003e\u003cp\u003eHedera Profiling 2 ctDNA test panel includes SNVs, Indels, CNVs, Fusions, and MSI\u003c\/p\u003e\u003cp\u003eThe panel detects a broad range of cfDNA variants as well as Microsatellite Instability (MSI).\u003c\/p\u003e\u003cp\u003eResults from a unique international (8 countries), multicenter (11 centers), analytical validation study\u003c\/p\u003e\u003cp\u003eResults based on 30 ng of input cfDNA (commercial reference control DNA) for all SNVs, Indels and Fusions with samples run on a NextSeq 2000 instrument.\u003c\/p\u003e\u003cp\u003e137 clinical cfDNA samples were run across 9 tumor types (lung, breast, colon, prostate, pancreatic, endometrial \u0026amp; cervical cancers, neuroblastoma, melanoma). Results based on clinical samples run on NextSeq 500\/550\/550Dx and Novaseq 6000 instruments. MSI method preliminarily trained on an additional set of 54 clinical samples.\u003c\/p\u003e\u003cp\u003eHigh observed sensitivity obtained with commercial reference control cfDNA testing is corroborated with real-life cfDNA clinical samples from 11 expert cancer centers\u003c\/p\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, BRAF, EGFR, ERBB2, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KEAP1, KIT, KRAS, MAP2K1, MET, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PTEN, RET, ROS1, STK11, TP53\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eT18-6LP223IR\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 2 ctDNA Test Panel (HP2)\u003c\/td\u003e\n\u003ctd\u003e18 tests\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor performance studies only, not authorized for diagnostic procedures until its clinical performance has been established and all local regulatory requirements for routine testing are met. Not available in all countries including the United States.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Default Title","offer_id":46798498267215,"sku":"T18-6LP223IR","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/653130a0baed54e0e893b602_n22_201.png?v=1789655462"},{"product_id":"hedera-profiling-3-ctdna-test-panel-hp3-t24-4lp324ir","title":"Hedera Profiling 3 ctDNA Test Panel (HP3), 43-Gene NGS Liquid Biopsy Kit, 24 Tests","description":"\u003cp\u003eHedera Profiling 3 (HP3) is a targeted 43-gene, hybrid-capture NGS liquid biopsy assay for profiling the most common solid tumors, including lung, breast, ovarian and prostate cancers. It detects SNVs, Indels, CNVs, Fusions and MSI status from as little as 10 ng of plasma cfDNA and includes more than 90% of the ESCAT Level I genes, BRCA1\/2 among them. 24 tests per kit.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 43 gene-panel for the detection of SNVs, Indels, CNVs, Fusions and MSI status across most common tumor types in a single, DNA-only liquid biopsy assay\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e \u0026gt;90% of the ESCAT Level I genes are included in the panel including BRCA1\/2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days, with as little as 10ng of cell-free DNA (30ng input recommended)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, save time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique fusions detection method on DNA:\u003c\/strong\u003e Cutting-edge proprietary technology to detect fusions in ctDNA with unmatched precision, enhancing the accuracy of complex variants detection in plasma samples\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd6e894f871ef04c253e5_HP3-workflow.png\" alt=\"Hedera Profiling 3 ctDNA test panel sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e148 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e43\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMultiplexing\u003c\/td\u003e\n\u003ctd\u003eup to 4 samples on a NextSeq 500\/550 instrument (MID Output flow cell)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSample size\u003c\/td\u003e\n\u003ctd\u003emin 5 mL plasma required (cfDNA BCT tubes by Streck recommended for blood collection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ecfDNA input\u003c\/td\u003e\n\u003ctd\u003emin 10ng cfDNA (30ng of cfDNA recommended)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary preparation method\u003c\/td\u003e\n\u003ctd\u003ehybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallowing error correction and preventing index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e24\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Breast Cancer, Ovarian Cancer, Prostate Cancer, Colorectal Cancer, Urothelial Carcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, ATM, BRAF, BRCA1, BRCA2, CD274, CTNNB1, CUL3, EGFR, ERBB2, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KEAP1, KIT, KRAS, MAP2K1, MET, NFE2L2, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDGFRA, PIK3CA, POLE, PTEN, RB1, RET, ROS1, SMARCA4, STK11, TP53\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eT24-4LP324IR\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 3 ctDNA Test Panel (HP3)\u003c\/td\u003e\n\u003ctd\u003e24 tests\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor performance studies only, not authorized for diagnostic procedures until its clinical performance has been established and all local regulatory requirements for routine testing are met. Not available in all countries including the United States.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Default Title","offer_id":46798498168911,"sku":"T24-4LP324IR","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/69dccb4c587d1305b2225932_HP3-box-1x.png?v=1789655463"},{"product_id":"hedera-profiling-rna-tissue-test-panel-hp-rna-t24-8rp126irm","title":"Hedera Profiling RNA Tissue Test Panel (HP RNA), 43-Gene NGS Fusion \u0026 Expression Kit, 24 Tests","description":"\u003cp\u003eHedera Profiling RNA (HP RNA) is a 43-gene, hybrid-capture NGS panel for FFPE tissue RNA. It detects fusions with partner-agnostic discovery, gene expression, alternative splicing and actionable exon skipping, and includes all major ESCAT genes and all OncoKB Level 1, 2 and 3 genes for solid tumors. Works with as little as 30 ng of RNA; 24 tests per kit.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 43 genes to detect fusions (partner-agnostic discovery), gene expression profiling, alternative splicing and splice variants and actionable exon skipping detection for functional insights\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e Includes all major ESCAT genes and all OncoKB Levels 1, 2, 3 for solid tumors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results within 5 calendar days, with as little as 30 ng of RNA\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, save time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd6e86757eb1945325a43_HP-RNA-workflow.png\" alt=\"Hedera Profiling RNA test panel sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e73.9 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e43 (splice-aware, exon boundary-targeted coverage)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e24 (3 captures of 8 samples)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series; Element Biosciences AVITI Systems\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecommended input amount\u003c\/td\u003e\n\u003ctd\u003emin 30 ng (50 ng recommended with \u0026gt;30% tumour content)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary enrichment method\u003c\/td\u003e\n\u003ctd\u003eHybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallows error correction and prevents index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Colorectal Cancer, Melanoma, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, AR, BRAF, BRCA1, BRCA2, CD274, CIC, CLDN18, EGFR, ERBB2, ERBB3, ERG, ESR1, ETV1, ETV6, EWSR1, FGFR1, FGFR2, FGFR2b, FGFR3, MAP2K1, MET, MYC, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PAX3, PAX8, PDGFB, PGR, PLAG1, PPARG, RAF1, RET, ROS1, SS18, STAT6, TMPRSS2, USP6\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eT24-8RP126IRM\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling RNA Tissue Test Panel (HP RNA)\u003c\/td\u003e\n\u003ctd\u003e24 tests\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures. This product is intended for laboratory research purposes only and is not intended for use in the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This product has not been cleared or approved by any regulatory authority for clinical or diagnostic use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Default Title","offer_id":46798498234447,"sku":"T24-8RP126IRM","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/69dccafd50a94e5b8190a7b8_HP-RNA-box-1x.png?v=1789655468"}],"url":"https:\/\/www.danyel.co.il\/collections\/hedera-dx.oembed","provider":"danyel biotech","version":"1.0","type":"link"}