{"title":"Bioprocess Media \u0026 Cell Therapy Reagents","description":null,"products":[{"product_id":"hyclone-adcf-antifoam-solution-sh30897-01","title":"HyClone™ ADCF antifoam solution","description":"\u003cp\u003eHyClone™ ADCF antifoam irradiated solution products have 3% active simethicone and has been shown to effectively prevent foam from occurring in cell culture systems, as well as to quickly eliminate foam already formed.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIrradiated Antifoam effectively prevents and dissipates foaming in cell culture systems.\u003c\/li\u003e\n\u003cli\u003eProvided in easy-to-use single-use bags.\u003c\/li\u003e\n\u003cli\u003eDesigned with tubing lines and fittings to enable easy connection and delivery to any cell culture system (customization possible).\u003c\/li\u003e\n\u003cli\u003eHyClone™ Antifoam is an emulsion with ~3% active simethicone.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe products are delivered in single‑use bags designed with tubing lines and fittings to enable easy connection and delivery to various cell culture systems.  \u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17826-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1 × 500 mL","offer_id":45982005690447,"sku":"SH30897.01","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"8 × 500 mL","offer_id":45982005723215,"sku":"SH30897.04","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-26792-original-png_e5bf1331-ec74-40b5-af28-d4c4eb8c9757.png?v=1785956329"},{"product_id":"cytodex-1-gamma-microcarriers-sterilized-dry-powder-17548701","title":"Cytodex™ 1 Gamma microcarriers (sterilized, dry powder)","description":"\u003cp\u003eMicrocarrier for general use in sterilized dry powder form.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGamma-sterilized and ready to use for quick culture start-up.\u003c\/li\u003e\n\u003cli\u003eDelivered in a convenient, single-use container system for easy transfer to various cell culture vessels.\u003c\/li\u003e\n\u003cli\u003eSupplied dry to save storage space and facilitate transportation.\u003c\/li\u003e\n\u003cli\u003eEnable culturing of anchorage-dependent cells in single-use bioreactor to eliminate the need for cleaning and cleaning validation.\u003c\/li\u003e\n\u003cli\u003eSupported by extensive product documentation to facilitate regulatory filing.\u003c\/li\u003e\n\u003cli\u003eSerum-free function testing to ensure performance\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eA general-purpose microcarrier\u003c\/p\u003e\n\n\u003cp\u003eSterilized Cytodex 1 Gamma is a general-purpose microcarrier particularly suitable for most established cell lines and for production of viruses or cell products from cultures of primary cells and normal diploid cell strains.\u003c\/p\u003e\n\n\u003cp\u003eCytodex 1 Gamma is designed by substituting a cross-linked dextran matrix with positively charged N, N-diethylaminoethyl (DEAE) groups distributed throughout the matrix.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/Scalable-ADCF-virus-production\"\u003eLearn how Cytodex 1 microcarriers were used in scalable ADCF virus production using HyClone VaccineXpress medium \u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17654-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29115815.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"3 kg","offer_id":45982014799951,"sku":"17548703","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"30 g","offer_id":45982014832719,"sku":"17548701","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"300 g","offer_id":45982014865487,"sku":"17548702","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-3794-original-png.png?v=1782739468"},{"product_id":"cytodex-3-gamma-microcarriers-sterilized-dry-powder-17548802","title":"Cytodex™ 3 Gamma microcarriers (sterilized, dry powder)","description":"\u003cp\u003eThe microcarrier of choice for cells that are difficult to culture in vitro - particularly for cells with an epithelial-like morphology.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGamma-sterilized and ready to use for quick culture start-up.\u003c\/li\u003e\n\u003cli\u003eDelivered in a convenient, single-use container system for easy transfer to various cell culture vessels.\u003c\/li\u003e\n\u003cli\u003eSupplied dry to save storage space and facilitate transportation.\u003c\/li\u003e\n\u003cli\u003eEnable culturing of anchorage-dependent cells in single-use bioreactor to eliminate the need for cleaning and cleaning validation.\u003c\/li\u003e\n\u003cli\u003eSupported by extensive product documentation to facilitate regulatory filing.\u003c\/li\u003e\n\u003cli\u003eSerum-free function testing to ensure performance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSuccessful serial subcultivation protocols\u003c\/p\u003e\n\u003cp\u003eCytodex 3 Gamma is designed by chemically coupling of a thin layer of denatured porcine collagen type 1 to the cross-linked dextran matrix. As the collagen surface layer can be digested by a variety of proteolytic enzymes, harvest of such cells from the microcarriers can be performed with maintained high cell viability and membrane integrity. This feature of Cytodex 3 Gamma is beneficial in the development of successful serial subcultivation protocols for scaling up culture volumes.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17654-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29115815.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"3 kg","offer_id":45982014767183,"sku":"17548803","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"30 g","offer_id":45991796932687,"sku":"17548801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"300 g","offer_id":45991796965455,"sku":"17548802","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-3794-original-png_74c7a945-17d3-45ab-a166-c91be63416d1.png?v=1782905956"},{"product_id":"cytodex-3-microcarriers-dry-powder-17048501","title":"Cytodex™ 3 microcarriers (dry powder)","description":"\u003cp\u003eThe microcarrier of choice for cells that may be difficult to culture in vitro .\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned for culture of primary cells or those with an epithelioid morphology, especially cells with low plating-efficiency or differentiated or sensitive cell-types which are normally difficult to grow, e.g. hepatocytes, endocrine cells.\u003c\/li\u003e\n\u003cli\u003eContains a layer of acid-denatured porcine collagen (gelatin) on the surface of the microporous matrix.\u003c\/li\u003e\n\u003cli\u003eDesigned to yield harvested cells of the highest viability.\u003c\/li\u003e\n\u003cli\u003eTransparent for easy microscopic examination of attached cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMicrocarrier culture\u003c\/p\u003e\n\u003cp\u003eMicrocarrier culture is a technique which makes possible the practical high yield culture of anchorage-dependent cells. Cytodex has been specifically developed for the culture of a wide range of animal cells in culture volumes ranging from a few ml to more than 6000 L. Using Cytodex in simple suspension culture systems provides yields of several million cells per mL.\u003c\/p\u003e\n\u003cp\u003eFormation\u003c\/p\u003e\n\u003cp\u003eFormed by chemically coupling a thin layer of denatured collagen to the cross-linked dextran matrix, this is the microcarrier of choice for cells that may be difficult to culture \u003ci\u003ein vitro\u003c\/i\u003e, and particularly for cells with an epithelial like morphology.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-12160-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/18111979.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"2.5 kg","offer_id":45982015553615,"sku":"17048525","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"5 kg","offer_id":45982015586383,"sku":"17048504","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"10 g","offer_id":45982015619151,"sku":"17048501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"100 g","offer_id":45982015651919,"sku":"17048502","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"500 g","offer_id":45982015684687,"sku":"17048503","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-5457-original-png_075e6e08-2a48-47c5-bd63-84e693ec1d29.png?v=1785956721"},{"product_id":"cytodex-1-microcarriers-dry-powder-17044802","title":"Cytodex™ 1 microcarriers (dry powder)","description":"\u003cp\u003eA general-purpose microcarrier for most established, anchorage-dependent cell lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGeneral-purpose microcarrier for most established, anchorage-dependent cell lines.\u003c\/li\u003e\n\u003cli\u003eContains positive charges throughout the microporous matrix.\u003c\/li\u003e\n\u003cli\u003eTransparent for easy microscopic examination of attached cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIt is particularly suitable for most established cell lines and for production of viruses or cell products from cultures of primary cells and normal diploid cell strains.\u003c\/p\u003e\u003cp\u003eHigh yield culture of anchorage-dependent cells\u003c\/p\u003e\u003cp\u003eMicrocarrier culture is a technique which makes possible the practical high yield culture of anchorage-dependent cells. Cytodex has been specifically developed for the culture of a wide range of animal cells in culture volumes ranging from a few mL to more than 6000 L. Using Cytodex in simple suspension culture systems provides yields of several million cells per mL.\u003c\/p\u003e\u003cp\u003eSuitable for most established cell lines\u003c\/p\u003e\u003cp\u003eFormed by substituting a cross-linked dextran matrix with positively charged DEAE* groups distributed throughout the matrix, is a general purpose microcarrier. It is particularly suitable for most established cell lines and for production of viruses or cell products from cultures of primary cells and normal diploid cell strains.\u003c\/p\u003e\u003cp\u003e* N, N-diethylaminoethyl\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-12160-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/18111979.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"2.5 kg","offer_id":45982019125327,"sku":"17044825","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"5 kg","offer_id":45982019158095,"sku":"17044804","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"25 g","offer_id":45982019190863,"sku":"17044801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"100 g","offer_id":45982019223631,"sku":"17044802","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"500 g","offer_id":45982019256399,"sku":"17044803","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-5450-original-png_161077a8-8de5-430e-9c2e-86c300ee8dea.png?v=1785956869"},{"product_id":"hyclone-actipro-cell-culture-media-sh31037-02","title":"HyClone™ ActiPro™ cell culture media","description":"\u003cp\u003eHyClone™ ActiPro™ cell culture media has been formulated to provide high yields of recombinant proteins in bioprocesses using Chinese hamster ovary (CHO) cell lines. The cultured medium is chemically defined, animal-derived component-free (ADCF), and optimized for high-yield protein expression and production in batch or CHO fed-batch cell culture processes.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDemonstrates high yields of recombinant protein\u003c\/li\u003e\n\u003cli\u003eDoes not contain hypoxanthine and thymidine (HAT supplement)\u003c\/li\u003e\n\u003cli\u003eChemically defined ADCF mAb media formulation\u003c\/li\u003e\n\u003cli\u003eProduction medium for batch or fed-batch fermentation processes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone™ ActiPro™ cell culture medium is available in both liquid and powder forms for cell culture bioprocesses. This chemically defined medium is intended for use in combination with \u003ca href=\"\/shop\/cell-culture-and-fermentation\/media-and-feeds\/specialty-media\/hyclone-actism-cell-culture-media-p-05498\"\u003eHyClone™ ActiSM™ medium\u003c\/a\u003e and \u003ca href=\"\/shop\/cell-culture-and-fermentation\/reagents-and-supplements\/feed-supplements\/hyclone-cell-boost-7a-supplement-p-06179\"\u003eCell Boost™ 7a\u003c\/a\u003e and \u003ca href=\"\/shop\/cell-culture-and-fermentation\/media-and-feeds\/feed-supplements\/hyclone-cell-boost-7b-supplement-p-06306\"\u003eCell Boost™ 7b supplements\u003c\/a\u003e. ActiPro™ media and supplements are formulated for industrial production of recombinant proteins, including those requiring complex post-translational modifications and correct protein folding. In addition, this engineered ActiPro™ system of media and supplements can significantly reduce production process time.\u003c\/p\u003e\n\n\u003cp\u003eThe ActiPro™ system is suitable for general cell culture biomanufacturing with CHO cell lines such as CHO-GS, CHO-K1, CHO-DG44, and CHO-S. ActiPro™ cell culture media and supplements were designed with adaptation and CHO protein production in mind. ActiPro™ media and supplements are balanced formulations of amino acids, vitamins, salts, trace elements, and other components, meeting the metabolic needs of CHO cells in production. The cell culture system does not contain peptides, hydrolysates, phenol red, 2-mercaptoethanol, or growth factors such as insulin, to ensure batch-to-batch consistency and increased cell culture bioprocess efficiency. For fast-growing CHO cells with higher carbon consumption, glucose supplementation is needed.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17793-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29871627.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 500 mL","offer_id":45982029676623,"sku":"SH31039.01","price":247.0,"currency_code":"ILS","in_stock":true},{"title":"Liquid \/ 1000 mL","offer_id":45982029709391,"sku":"SH31039.02","price":411.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 5 L","offer_id":45982029742159,"sku":"SH31037.01","price":1106.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 10 L","offer_id":45982029774927,"sku":"SH31037.02","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-26596-original-png_a49cf8df-26bd-4059-bced-3a64de4be840.png?v=1785957246"},{"product_id":"hepato9-mrna-transfection-kit-29873659","title":"Hepato9 mRNA transfection kit","description":"\u003cp\u003eHepato9 mRNA kit is a lipid nanoparticle (LNP) reagent that enables the rapid production of RNA-LNPs using the NanoAssemblr™ Spark™ instrument and is optimized for the in vitro delivery of these nanoparticles.\u003c\/p\u003e","brand":"Cytiva","offers":[{"title":"Spark","offer_id":45982052941903,"sku":"29873659","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/n1yuhdyCSEWV62uPx4Gslw-original-png_880e9b37-9d26-4030-89bd-929956ad018c.png?v=1785957961"},{"product_id":"neuro9-sirna-kits-29873656","title":"Neuro9 siRNA kits","description":"\u003cp\u003eNeuro9 siRNA kits are lipid nanoparticle (LNP) reagents that enable the production of siRNA-LNPs using the NanoAssemblr™ Spark™ instrument. siRNA-LNP generated using the Neuro9 siRNA transfection kit are optimized for the delivery of these nanoparticles into rat neurons.\u003c\/p\u003e","brand":"Cytiva","offers":[{"title":"Spark (29873656)","offer_id":45982053236815,"sku":"29873656","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Spark (29873655)","offer_id":45982053269583,"sku":"29873655","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/3iU6JNGtQV6kCIsI_HraWQ-original-png_f7224aef-1d19-4a93-88c1-74bb04003b2d.png?v=1785957968"},{"product_id":"hyclone-pf-cho-ls-and-pf-cho-mps-cell-culture-media-sh30333-02","title":"HyClone™ PF-CHO LS and PF-CHO MPS cell culture media","description":"\u003cp\u003eSupport growth of multiple CHO cell clones and production of a variety of recombinant proteins with HyClone PF-CHO and PF-CHO MPS media, versatile protein-free media developed to support the growth of multiple CHO cell clones and production of a variety of recombinant proteins.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllow for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eSupport growth in multiple cell culture systems\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP (21 CFR 820) guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone PF-CHO LS liquid and PF-CHO MPS powder media are versatile and protein-free. The media are developed to support the growth of multiple Chinese hamster ovary (CHO) cell clones and production of a variety of recombinant proteins with minimal adaptation.\u003c\/p\u003e\u003cp\u003ePF-CHO LS and PF-CHO MPS media are designed to support the dihydrofolate reductase (DHFR) selection\/amplification system. The media have been successfully tested in a variety of cell culture systems, including T-flasks, spinner flasks, and bioreactors. PF-CHO LS liquid and PF-CHO MPS are available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17784-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30333.01 \/ 5 L","offer_id":45982098489423,"sku":"SH30333.01","price":774.0,"currency_code":"ILS","in_stock":true},{"title":"SH30333.02 \/ 10 L","offer_id":45982098522191,"sku":"SH30333.02","price":1437.0,"currency_code":"ILS","in_stock":true},{"title":"SH30359.02 \/ 1000 mL","offer_id":45982098554959,"sku":"SH30359.02","price":311.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23322-original-png_01bad515-02ae-4bfe-be2a-7d9e01126aa5.png?v=1785958262"},{"product_id":"genvoy-ilm-reagents-and-kits-1002763","title":"GenVoy-ILM™ reagents and kits","description":"\u003cp\u003eGenVoy-ILM™ reagents are LNP reagents that enable the production of RNA-LNPs using the NanoAssemblr™ Ignite™ and Ignite+™ instruments. The resulting LNPs formed by mixing GenVoy-ILM™ and nucleic acids using Ignite™ and Ignite+™ instruments feature a homogeneous core structure. This reagent has been designed to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnable target validation: The excellent transfection efficiency and remarkably low cytotoxicity exhibited by GenVoy-ILM™ LNPs enable effective RNA-mediated gene silencing, gene expression, and gene editing in primary cells, stem cells, and non-adherent cells.\u003c\/li\u003e\n\u003cli\u003eDemonstrate therapeutic performance: These reagents are designed to enable effective formulation in developing proof of concept data for RNA-based therapeutics.\u003c\/li\u003e\n\u003cli\u003eEnable process development: The resulting formulation can be used as a reference formulation at all development scales to establish a scalable process for GMP manufacturing to support clinical development\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis reagent is available in two formats, smaller and larger volumes for different formulation needs, with or without added dye for visualization.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eGenVoy-ILM™ demo on the NanoAssemblr™ Ignite™ system\u003c\/p\u003e\n\n\u003cp\u003e\u003ciframe allowfullscreen=\"\" allowtransparency=\"true\" class=\"vidyard_iframe\" frameborder=\"0\" height=\"360\" referrerpolicy=\"no-referrer-when-downgrade\" scrolling=\"no\" src=\"\/\/play.vidyard.com\/ZcqTxsshgwJjYf1xdRxfp9.html?\" title=\"GenVoy Ignite Video Demo\" width=\"640\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/0NIN1182.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Ignite, Ignite+ (1002763)","offer_id":45982111498319,"sku":"1002763","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite, Ignite+ (1002771)","offer_id":45982111531087,"sku":"1002771","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite, Ignite+ (1002773)","offer_id":45982111563855,"sku":"1002773","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite, Ignite+ (1002769)","offer_id":45982111596623,"sku":"1002769","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite, Ignite+ (1002775)","offer_id":45982111629391,"sku":"1002775","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/sDyieNvbSLiZkTUUKY4mkg-original-png_98021580-9989-4df5-b0d7-9cc91e7250eb.png?v=1785958429"},{"product_id":"xuri-il-2-growth-factor-29062790","title":"Xuri™ IL-2 growth factor","description":"\u003cp\u003eInterleukin-2 available in two formats – powder or liquid. This growth factor reliably activates T lymphocytes for efficient cell expansion. Meets USP \u0026lt;1043\u0026gt; for cell therapy ancillary material as applicable to supplier.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGain peace of mind. Produced under a certified GMP license regularly qualified by licensing authorities. Sterility- and endotoxin-tested according to USP.\u003c\/li\u003e\n\u003cli\u003eReproducible. No need to revalidate each new lot.\u003c\/li\u003e\n\u003cli\u003eManage contamination risk. Easily connect Xuri IL-2 Syringe to a bag via Luer connection.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFunctionality of this product is based on biological activity assays. Animal component-free. All Xuri reagents and media are compatible with Xuri Cell Expansion System.\u003c\/p\u003e\u003cp\u003eInterleukin-2\u003c\/p\u003e\u003cp\u003eInterleukin-2 promotes the growth, activity and maintenance of T and B lymphocytes. IL-2 is key in a number of cell and cell-based gene therapies.\u003c\/p\u003e\u003cp\u003eRegulatory support\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/support\/quality\/regulatory-support\"\u003eRegulatory support file (RSF) is available\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eQuality statement\u003c\/p\u003e\u003cp\u003eXuri growth factors are manufactured, tested, and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› ‘Ancillary materials for cell, gene and tissue-engineered products’ has been followed in the design of these products.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17164-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29083091.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Standard \/ Standard","offer_id":45982111891535,"sku":"29062789","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Liquid \/ 1 mg","offer_id":45982111924303,"sku":"29295127","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 1 mg","offer_id":45982111957071,"sku":"29062790","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-27179-original-png_4232634e-62f6-44c0-8487-5541c9baae71.png?v=1785958436"},{"product_id":"xuri-t-cell-expansion-medium-29185230","title":"Xuri™ T cell expansion medium","description":"\u003cp\u003eEnables cell expansion of human T lymphocytes. It follows USP for cell therapy ancillary material.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRapid cell proliferation for faster manufacturing.\u003c\/li\u003e\n\u003cli\u003eIntegrated tubing and ports allowing functionally closed system connections.\u003c\/li\u003e\n\u003cli\u003eConsistent performance across batches.\u003c\/li\u003e\n\u003cli\u003eDedicated cell therapy ancillary product following USP for ex vivo cultivation.\u003c\/li\u003e\n\u003cli\u003eChemically defined and free from any human or animal derived components.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRapid cell proliferation for faster manufacturing\u003c\/p\u003e\u003cp\u003eXuri T cell expansion medium enables elevated rates of proliferation of viable human T lymphocytes to high cell densities. Cultivation time becomes more flexible, enabling the reach of the desired cell number faster even when working with challenging cells due to donor variability.\u003c\/p\u003e\u003cp\u003eReduce risk with a functionally closed system\u003c\/p\u003e\u003cp\u003eXuri T cell expansion medium is shipped in bags equipped with medical grade PVC tubing and fitted with male and female Luer lock ports, making sure that the bag can be sterile welded to Xuri cellbag bioreactors. This provides the flexibility to add supplements to the bag within a functionally closed system.\u003c\/p\u003e\u003cp\u003eMinimize variability for consistent performance\u003c\/p\u003e\u003cp\u003eXuri T cell expansion medium is manufactured under a strict quality management system and the fully validated production process ensures consistency across batches, improving control in achieving the desired cell numbers.\u003c\/p\u003e\u003cp\u003eUSP \u0026lt;1043\u0026gt; compliance\u003c\/p\u003e\u003cp\u003eA smooth submission process is key when dealing with cell therapy regulatory requirements. To help users assess and document production processes, Cytiva supplies Xuri T cell expansion medium with a comprehensive documentation support package that meets USP \u0026lt;1043\u0026gt; ‘ancillary materials for cell, gene, and tissue-engineered products’, within the responsibilities applicable to a supplier.\u003c\/p\u003e\u003cp\u003eEnd user responsibility\u003c\/p\u003e\u003cp\u003eOther aspects of USP \u0026lt;1043\u0026gt; will be the responsibility of the end user to assess. Cytiva cannot fulfill USP \u0026lt;1043\u0026gt; in regard to application and therapy specific aspects (e.g., use in finished therapeutic, assessment of removal from a finished therapeutic and possibly biocompatibility, cytotoxicity or adventitious agent testing). The product is chemically defined and free from any human or animal derived components.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-18382-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29112375.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1000 mL","offer_id":45982115299407,"sku":"29185231","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Standard","offer_id":45982115332175,"sku":"29185230","price":0.0,"currency_code":"ILS","in_stock":true}]},{"product_id":"genvoy-ilm-t-cell-kits-for-mrna-1000701","title":"GenVoy-ILM™ T cell kits for mRNA","description":"\u003cp\u003eGenVoy-ILM™ T cell Kit for mRNA is a lipid nanoparticle (LNP) reagent mix optimized for the delivery of mRNA or CRISPR Cas9 mRNA with gRNA into human primary T cells using LNPs prepared on the NanoAssemblr™ Spark™ and Ignite™ systems.\u003c\/p\u003e\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eGenVoy-ILM™ T cell Kits for mRNA offers the following benefits:\u003c\/p\u003e\n\n\u003cul\u003e\n\t\u003cli class=\"-font--body\"\u003e\n\u003cstrong\u003eHighly efficient knockout and expression:\u003c\/strong\u003e The mRNA or mRNA\/sgRNA can be delivered into activated human primary T cells consistently with high gene knockout efficiency.\u003c\/li\u003e\n\t\u003cli class=\"-font--body\"\u003e\n\u003cstrong\u003eHigh cell viability:\u003c\/strong\u003e Maintain high T cell viability, even after sequential genetic manipulation.\u003c\/li\u003e\n\t\u003cli class=\"-font--body\"\u003e\n\u003cstrong\u003eScalable:\u003c\/strong\u003e Scale your cell therapy research on the NanoAssemblr™ platform from discovery to preclinical.\u003c\/li\u003e\n\t\u003cli class=\"-font--body\"\u003e\n\u003cstrong\u003eValidated with T cell manufacturing workflow:\u003c\/strong\u003e Optimized and validated for downstream T cell culture workflow.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThe kits enable researchers to establish a clinically relevant and scalable method for \u003cem\u003eex vivo\u003c\/em\u003e gene delivery and gene editing to advance the development of T cell therapies. These kits can be used at various stages of cell therapy research and development from discovery to preclinical across the NanoAssemblr™ platforms.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eGreater ratio of engineered T cells compared to electroporation (EP)\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eUsing the GenVoy-ILM™ T cell Kit for mRNA to deliver mRNA into activated human primary T cells results in an increased number of engineered T cells. This method demonstrates a more effective gene delivery method compared to EP.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/jZUKP9BQSEulL99fjFiXWA-large\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eTransfection efficiency was measured by protein expression via flow cytometry at 24 and 48 hours post-treatment. EP was performed by following the manufacturer’s protocol, and LNP treatment was performed following the GenVoy-ILM™ T cell Kit for mRNA on Spark™ protocol. Untreated cells (UT) were used as control. **p\u0026lt;0.01, ****p\u0026lt;0.0001 by one-way ANOVA.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eUniform cellular protein expression\u003c\/p\u003e\n\n\u003cp\u003eEngineering human primary T cells using the GenVoy-ILM™ T cell Kit for mRNA results in highly uniform protein expression across the treated cell population.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/1CPxSKqlTTSsuN91NrkbTg-original-png\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eRepresentative mean fluorescence intensity (MFI) plots of cell surface protein expression were generated using flow cytometry at 24 and 48 hours post-treatment. EP was performed by following the manufacturer’s protocol. Untreated cells (UT) were used as controls.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eHighly viable T cells\u003c\/p\u003e\n\n\u003cp\u003eActivated human primary T cells remain highly viable after \u003cem\u003eex vivo\u003c\/em\u003e gene delivery using the GenVoy-ILM™ T cell Kit for mRNA.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/mCKHQJyVQlWPxdADf2_KoQ-original-png?v=343d1041\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eCell viability was measured via flow cytometry at 24 and 48 hours post-treatment. EP was performed by following the manufacturer’s protocol, and LNP treatment was performed following the GenVoy-ILM™ T cell Kit for mRNA on Spark™ protocol. Untreated cells (UT) were used as controls. ****p\u0026lt;0.0001 by one-way ANOVA.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eMulti-step engineering of T cells for off-the-shelf cell therapy\u003c\/p\u003e\n\n\u003cp\u003eAchieve highly efficient genome editing knockouts in combination with high levels of CD19 CAR expression. This allows for the engineering of functional and viable “universal” CAR T cells that effectively kill CD19+ tumor cells.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/V48HbQ3hQkqHupJqZpOZEA-original-png?v=60dbe059\" style=\"max-width: 1150px;\"\u003e\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eA) Schematic illustration of experiment. mRNA-LNPs containing sgRNA + Cas9 mRNA were added to primary T cells. Cells expanded prior to treatment with CD19 CAR mRNA-LNPs. At 24 hours post CAR mRNA-LNP treatment, CD19+ T cell killing assay was conducted for 16 hours. B) TCR knockout efficiency was assessed. Starting sample was TCR negative selected to further purify the TCR- population. C) Left: Percent CD19 CAR expression 24 hours after treatment with CAR mRNA-LNPs at 3.2 μg RNA\/million cells, when population is TCR+, or TCR−. Right: Corresponding cell viabilities, normalized to the untreated population. D) Functional killing of CD19+ B cells (SUP-B15) by either UT, TCR+\/CAR+, or gene-edited TCR−\/CAR+ T cells at the indicated effector to target ratios (E:T). For all, a dose of 3.2 μg RNA\/million cells was applied. Error bars represent standard deviation. Statistical significance was evaluated using t-tests or one-way ANOVA among the shown groups (2).\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eScale up from discovery to preclinical\u003c\/p\u003e\n\n\u003cp\u003eThe data demonstrates that the GenVoy-ILM™ T cell Kits and the scalable NanoAssemblr™ platform enable robust and equivalent performance on both the Spark™ and Ignite™ instruments enabling scale up from discovery to preclinical.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/_6AxVcEQSKKQptBRUsXjCw-original-png?v=fe1a20aa\" style=\"max-width: 1250px;\"\u003e \u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/812C6PHyQ7eq6Rr6GInWrw-original-png?v=04b8a698\" style=\"max-width: px;\"\u003e\u003c\/p\u003e\n\n\u003cp class=\"-font--minus-1\"\u003eA) GFP and B) CD19 CAR transfection efficiency 24 hours post mRNA-LNP addition. C) Levels of single target (T cell receptor, TCR) knockout, and D) Double target (TCR and CD52) knockout through sgRNA and Cas9 mRNA delivery. E) Functional killing of CD19+ B cells (SUP-B15) in a 16-hour co-culture experiment. For all: a dose of 3.2 μg RNA\/million cells was applied to human primary T cells. RNA-LNPs were prepared according to the GenVoy-ILM™ T cell Kit for mRNA on Spark™ or Ignite™ user guides. Average gene expression and gene knockout was detected by flow cytometry showing at minimum n=8 independent RNA-LNP preparations and n=2 donors. Functional killing performance was detected by flow cytometry showing n=2 independent RNA-LNP preparations and n=2 donors. Error bars represent standard deviation with statistical significance evaluated using t-tests among selected groups (2).\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eKit components\u003c\/p\u003e\n\n\u003cdiv class=\"table-responsive\"\u003e\n\u003ctable class=\"table table-bordered\"\u003e\n\t\u003cthead\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003e \u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eGenVoy-ILM™ T cell Kit for mRNA, Spark™, (Part no. 1000700)\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eGenVoy-ILM™ T cell Kit for mRNA w\/ 5 Spark™ cartridge, (Part no. 1000683)\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eGenVoy-ILM™ T cell Kit for mRNA, Ignite™, 3 mL, (Part no. 1001144)\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eGenVoy-ILM™ T cell Kit for mRNA, Ignite™, 6 mL, (Part no. 1001161)\u003c\/th\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/thead\u003e\n\t\u003ctbody\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eLipid mix\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e90 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e90 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e3 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eFormulation buffer (10X)\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e30 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e30 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e2 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e4 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eDilution buffer (10X)\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e900 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e900 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e40 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e80 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eCryopreservation buffer (2X)\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e3 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eApolipoprotein-E (ApoE)\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e50 µg\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e50 µg\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e500 µg\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e500 µg x 2\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eSpark Cartridges\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e5\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/01001343.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Ignite (1001144)","offer_id":45982115627087,"sku":"1001144","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite (1001161)","offer_id":45982115659855,"sku":"1001161","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Spark (1000701)","offer_id":45982115692623,"sku":"1000701","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Spark (29874064)","offer_id":45982115725391,"sku":"29874064","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/W-GiOF0YT7G2-ss2TM1BvQ-original-png_b3850b8e-04d7-4599-9cd8-cfb896f2b679.png?v=1785958486"},{"product_id":"hyclone-ccm3-cell-culture-media-sh30061-03","title":"HyClone™ CCM3 cell culture media","description":"\u003cp\u003eSerum-free medium designed for Sf9 insect cells.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTailored for Sf9 cells.\u003c\/li\u003e\n\u003cli\u003eDeveloped to support performance and increased process yields of multiple cell culture platforms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSerum-free medium designed to provide a consistent nutrient supply without the need for serum prescreening.\u003c\/p\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL","offer_id":45982116479055,"sku":"SH30065.02","price":283.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 10 L","offer_id":45982116511823,"sku":"SH30061.03","price":1156.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23422-original-png_938a7836-0818-45be-8c09-38b94773d3a3.png?v=1785958499"},{"product_id":"hyclone-sfx-insect-cell-culture-media-sh30350-02","title":"HyClone™ SFX-Insect cell culture media","description":"\u003cp\u003eSerum-free medium supports recombinant protein production with multiple insect cell lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production.\u003c\/li\u003e\n\u003cli\u003eComplexed lipids for enhanced stability.\u003c\/li\u003e\n\u003cli\u003eSupports direct and sequential adaptation\u003c\/li\u003e\n\u003cli\u003eHigh performance growth in multiple culture systems including high density bioreactors.\u003c\/li\u003e\n\u003cli\u003eManufactured using ISO 9001 and ISO 13485 certified processes according to 21 CFR 820 medical device current good manufacturing practices (cGMP).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSFX-Insect medium provides excellent growth of many key insect cell lines, including Sf9, Sf21, High Five (T.ni) and D.Mel-2 cells, while requiring minimal adaptation. Additionally, SFX-Insect medium has been successfully tested in a variety of culture systems ranging from T-flasks, shaker flasks, and various traditional and disposable bioreactors. SFX-Insect medium is available as liquid or powder medium in bottles, bags, or custom packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17783-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L","offer_id":45982119854159,"sku":"SH30350.02","price":935.0,"currency_code":"ILS","in_stock":true},{"title":"6 × 1000 mL","offer_id":45982119886927,"sku":"SH30278.LS","price":1105.0,"currency_code":"ILS","in_stock":true},{"title":"10 L","offer_id":45982119919695,"sku":"SH30350.03","price":1799.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982119952463,"sku":"SH30278.02","price":205.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23307-original-png_732695e0-a41d-4b37-8ae0-430728d22bfb.png?v=1785958523"},{"product_id":"hyclone-sfm4cho-utility-powder-cell-culture-media-sh30517-01","title":"HyClone™ SFM4CHO-Utility powder cell culture media","description":"\u003cp\u003eA versatile protein-free cell culture media designed for the production of recombinant proteins in suspension cultures.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eSupports multiple CHO clones\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eSupports growth in multiple cell culture systems\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone SFM4CHO-Utility is a versatile cell culture medium designed to support the growth of multiple Chinese hamster ovary (CHO) cell clones and production of a variety of recombinant proteins. The medium enables excellent growth of many CHO cells with minimal adaptation.\u003c\/p\u003e\u003cp\u003eSFM4CHO-Utility medium has been designed to support the dihydrofolate reductase (DHFR) selection\/amplification system. The medium has been successfully tested in a variety of cell culture systems, including T-flasks, spinner flasks and bioreactors. SFM4CHO-Utility is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17571-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L","offer_id":45982121689167,"sku":"SH30517.01","price":727.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23315-original-png_721cb0e7-563c-42ed-9007-1f85e095a49e.png?v=1785958528"},{"product_id":"hyclone-cell-boost-kit-sh30890","title":"HyClone™ Cell Boost™ Kit","description":"\u003cp\u003eNutrient kit contains one 100 g bottles of each of Cell Boost™ 1 through Cell Boost™ 6.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChemically defined\u003c\/li\u003e\n\u003cli\u003eAnimal-derived component-free\u003c\/li\u003e\n\u003cli\u003eProtein-free\u003c\/li\u003e\n\u003cli\u003eManufactured in cGMP (21 CFR 820) compliant and ISO9001 certified facilities\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone™ Cell Boost™ supplements each provide an exclusive selection of nutrients such as amino acids, vitamins, lipids, cholesterol, glucose and\/or growth factors in complements optimized for multiple mammalian cell types. All Cell Boost™ supplements are chemically defined and contain no animal-derived components. The Cell Boost™ kit contains 100 g of each of six Cell Boost™ products. The supplements are designed to increase cell productivity in a variety of cell lines.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17617-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30890 \/ 1 six bottle 100 g","offer_id":45982124146767,"sku":"SH30890","price":4395.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23410-original-png_b5a2109d-f5dd-4b92-b1ed-570086dc3dcd.png?v=1785958545"},{"product_id":"hyclone-hycell-cho-cell-culture-media-sh30933-01","title":"HyClone™ HyCell™ CHO cell culture media","description":"\u003cp\u003eChemically defined (CD) and animal-derived component-free (ADCF) HyClone™ medium for Chinese hamster ovary (CHO) cell culture.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHyCell™ CHO media are chemically defined and animal-derived component-free.\u003c\/li\u003e\n\u003cli\u003eThese CHO cell culture media are designed for high yield of CHO cells and for recombinant protein production.\u003c\/li\u003e\n\u003cli\u003eHyCell™ CHO allows direct or sequential adaptation.\u003c\/li\u003e\n\u003cli\u003eThis chemically defined CHO medium is designed for large-scale culture applications, including perfusion and fed-batch feeding strategies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyCell™ CHO media are developed for Chinese hamster ovary (CHO) cell culture in bioprocessing applications. These CHO media support regulatory compliance and are chemically defined (CD) and animal-derived component-free (ADCF). HyCell™ media have been specifically formulated to provide excellent performance, support high peak CHO cell density, and enhance product yield and quality. These chemically defined media can be used for batch, fed-batch, or perfusion applications in multiple cell culture platforms ranging from shake flasks to large-scale bioreactors.\u003c\/p\u003e\n\n\u003cp\u003eHyCell™ CHO media containing hypoxanthine and thymidine (HT) are production media, while HyCell™ CHO media without HT are compatible with selection systems. For a long shelf-life and compatibility with glutamine synthetase (GS) systems, please note that neither of these formulations include L-glutamine. The recommended L-glutamine concentration is 4 to 6 mM.\u003c\/p\u003e\n\n\u003cp\u003eHyCell™ CHO media formulations are available in both liquid media and powdered formats for use in cell culture bioprocessing applications.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17552-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L","offer_id":45982124245071,"sku":"SH30933.01","price":1564.0,"currency_code":"ILS","in_stock":true},{"title":"10 L","offer_id":45982124277839,"sku":"SH30933.02","price":2123.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL PETE bottle","offer_id":45982124310607,"sku":"SH30934.01","price":403.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23342-original-png_125eac1e-bc07-4749-b968-82634d84fcc5.png?v=1785958549"},{"product_id":"hyclone-cell-boost-4-supplement-sh30857-01","title":"HyClone™ Cell Boost™ 4 Supplement","description":"\u003cp\u003eSupplements cell culture with amino acids, vitamins, glucose, trace elements, and growth factors. Manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern manufacturing  processes, Cell Boost™ 4 is chemically defined (CD), animal-derived component-free (ADCF), protein-free, and hydrolysate-free.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid feed solution in addition to a dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell yield in fed-batch cultures by supplementing the cell culture medium to replace nutrients depleted during cell culture. HyClone™ Cell Boost™ 4 Supplement provides amino acids, vitamins, glucose, trace elements, and growth factors to support fed-batch cultures suitable for research and bioprocessing applications. It is available as a convenient ready-to-use liquid feed solution or as a dry powder feed to be hydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis HyClone™ cell culture supplement has been developed for recombinant protein production with various cell lines including Chinese hamster ovary (CHO) cell line.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eSupplement 100 to 200 mL\/L, one or more times, starting during early- to mid-growth phase. This is expected to be day 2 to 4. Start the culture at a reduced volume according to anticipated feed volumes. Continue supplementation daily until the final volume is reached. It is recommended to monitor L- glutamine separately and supplement as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17569-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728533.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982124703823,"sku":"SH30857.01","price":1414.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982124736591,"sku":"SH31116.02","price":768.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50056-original-png_d29f20a7-3466-446a-afaf-7306b057b60d.png?v=1785958553"},{"product_id":"hyclone-cell-boost-1-supplement-sh30584-02","title":"HyClone™ Cell Boost™ 1 Supplement","description":"\u003cp\u003eSupplements cell culture with amino acids, vitamins, and glucose and manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern cell culture manufacturing processes, Cell Boost™ 1 is chemically defined (CD), animal-derived component-free (ADCF), and protein-free. It does not contain L-glutamine, poloxamer 188, or hydrolysates.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid feed solution in addition to the dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell growth in fed-batch cultures by supplementing the cell culture medium to boost nutrients depleted during culture. HyClone™ Cell Boost™ 1 Supplement provides nutrients such as amino acids, vitamins, and glucose to support fed-batch cultures in research and bioprocessing applications. It is available as a convenient ready-to-use liquid solution or as a dry powder supplement to be hydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis cell culture medium supplement has been developed for recombinant protein production with various cell lines including Chinese hamster ovary (CHO) and human embryonic kidney (HEK) 293 cells.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eSupplement 100 to 200 mL\/L, one or more times, starting during early- to mid-growth phase. This is expected to be day 2 to 4. Start the culture at a reduced volume according to anticipated feed volumes. Continue supplementation daily until the final volume is reached. It is recommended to monitor L- glutamine separately and supplement as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17566-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728526.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982124834895,"sku":"SH30584.02","price":921.0,"currency_code":"ILS","in_stock":true},{"title":"500 mL","offer_id":45982124867663,"sku":"SH31113.01","price":524.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982124900431,"sku":"SH31113.02","price":748.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50053-original-png_80ddb886-bf55-423b-baa9-017c1112c6d2.png?v=1785958557"},{"product_id":"hyclone-cell-boost-7a-and-7b-supplements-sh31027-07","title":"HyClone™ Cell Boost™ 7a and 7b supplements","description":"\u003cp\u003eHyClone™ Cell Boost™ 7a and Cell Boost™ 7b supplements improve productivity and cell yield in fed-batch cultures when using Chinese hamster ovary (CHO) cell lines by supplementing the cell culture medium to replace nutrients depleted during cell culture.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDemonstrated high yields of recombinant proteins (e.g., mAbs \u0026gt; 5 g\/L) in fed-batch processes.\u003c\/li\u003e\n\u003cli\u003eChemically defined (CD) and animal-derived component-free (ADCF)\u003c\/li\u003e\n\u003cli\u003eFree of growth factors (such as insulin), peptides, hydrolysates, phenol red, or 2-mercaptoethanol, ensuring batch-to-batch consistency and increased cell culture process efficiency\u003c\/li\u003e\n\u003cli\u003eConcentrated feeds that complement each other and are used together.\u003c\/li\u003e\n\u003cli\u003eAvailable as a ready-to-use liquid feed solution in addition to a dry powder format.\u003c\/li\u003e\n\u003cli\u003eAccompanied with detailed protocols for use to maximize output.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCell Boost™ 7a and 7b supplements are intended for use together in defined concentrations. Their compositions:\u003c\/p\u003e\n\n\u003ctable style=\"width:100%;\"\u003e\n\t\u003ctbody\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd\u003e\u003cstrong\u003eHyClone™ Cell Boost™ 7a supplement\u003c\/strong\u003e\u003c\/td\u003e\n\t\t\t\u003ctd\u003e\u003cstrong\u003eHyClone™ Cell Boost™ 7b supplement\u003c\/strong\u003e\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd\u003eCell Boost™ 7a supplement has a pH close to neutral and contains amino acids, vitamins, salts, trace elements, and glucose.\u003c\/td\u003e\n\t\t\t\u003ctd\u003eCell Boost™ 7b supplement has an alkaline pH and is a concentrated solution of amino acids.\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cbr\u003e\n\u003cp\u003eCell Boost™ supplements are used as an essential part of a cell culture feed strategy to enhance cell culture performance and increase product yield. Use in combination with HyClone™ ActiPro™ and ActiSM™ media for general biomanufacturing with CHO cell lines such as CHO-GS, CHO-K1, CHO-DG44, and CHO-S.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/iFaIzgo-RHm7VSd65P8PWw-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29136546.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"7a \/ Liquid \/ 500 mL","offer_id":45982124933199,"sku":"SH31119.01","price":591.0,"currency_code":"ILS","in_stock":true},{"title":"7a \/ Liquid \/ 1000 mL","offer_id":45982124965967,"sku":"SH31119.02","price":1177.0,"currency_code":"ILS","in_stock":true},{"title":"7a \/ Powder \/ 1 L","offer_id":45982124998735,"sku":"SH31026.07","price":1052.0,"currency_code":"ILS","in_stock":true},{"title":"7a \/ Powder \/ 5 L","offer_id":45982125031503,"sku":"SH31026.01","price":4352.0,"currency_code":"ILS","in_stock":true},{"title":"7a \/ Powder \/ 10 L","offer_id":45982125064271,"sku":"SH31026.02","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"7b \/ Liquid \/ 100 mL","offer_id":45982125097039,"sku":"SH31120.01","price":285.0,"currency_code":"ILS","in_stock":true},{"title":"7b \/ Liquid \/ 500 mL","offer_id":45982125129807,"sku":"SH31120.02","price":962.0,"currency_code":"ILS","in_stock":true},{"title":"7b \/ Liquid \/ 1000 mL","offer_id":45982125162575,"sku":"SH31120.03","price":1732.0,"currency_code":"ILS","in_stock":true},{"title":"7b \/ Powder \/ 1 L","offer_id":45982125195343,"sku":"SH31027.07","price":1521.0,"currency_code":"ILS","in_stock":true},{"title":"7b \/ Powder \/ 500 mL","offer_id":45982125228111,"sku":"SH31027.01","price":848.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50059-original-png_49dc0875-8087-40b8-85cf-687cfa20a831.png?v=1785958557"},{"product_id":"hyclone-cdm4mab-cell-culture-media-sh30800-01","title":"HyClone™ CDM4MAb cell culture media","description":"\u003cp\u003eHyClone™ CDM4MAb is a chemically defined and animal-derived component-free (ADCF) medium. This regulatory-friendly medium is developed to increase process yields for the manufacture of antibodies and antibody fragments for therapeutic use in a variety of engineered hybridoma and myeloma cell lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnimal-derived component-free.\u003c\/li\u003e\n\u003cli\u003eChemically defined formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and monoclonal antibody (MAb) production.\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCDM4MAb medium has been successfully tested in a variety of culture systems, including T-flasks, shaker flasks, and bioreactors including fed-batch and perfusion cultures. \u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17560-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL bottle","offer_id":45982125391951,"sku":"SH30802.02","price":370.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 5 L bottle","offer_id":45982125424719,"sku":"SH30800.01","price":1082.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23418-original-png_a37664bd-a622-4bec-abf4-dfd131073d33.png?v=1785958563"},{"product_id":"hyclone-cdm4permab-cell-culture-media-sh30872-01","title":"HyClone™ CDM4PERMAb cell culture media","description":"\u003cp\u003eChemically defined ADCF media for use with PER.C6 cells.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnimal-derived component-free\u003c\/li\u003e\n\u003cli\u003eChemically defined formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eComponent traceability\u003c\/li\u003e\n\u003cli\u003eManufactured according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone CDM4PERMAb medium has a chemically defined and animal-derived component-free (ADCF) formulation. This high-performance cell culture medium has been developed to increase process yields in the production of human antibodies and recombinant proteins using PER.C6 technology. The medium has been successfully tested in a variety of applications, including fed-batch bioreactor cultures. CDM4PERMAb is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17563-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L bottle","offer_id":45982125326415,"sku":"SH30872.01","price":1082.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL bottle","offer_id":45982125359183,"sku":"SH30871.02","price":369.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-27589-original-png_ba8a7338-d2cd-4680-8143-3c6244f03873.png?v=1785958563"},{"product_id":"hyclone-sfm4insect-cell-culture-media-sh30912-01","title":"HyClone™ SFM4Insect cell culture media","description":"\u003cp\u003eADCF (animal-derived component-free) medium supports recombinant protein production with multiple insect cell lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor use with the baculovirus expression vector system (BEVS).\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production.\u003c\/li\u003e\n\u003cli\u003eComplexed lipids for enhanced stability.\u003c\/li\u003e\n\u003cli\u003eSupports multiple insect cell lines.\u003c\/li\u003e\n\u003cli\u003eSupports direct or sequential adaptation.\u003c\/li\u003e\n\u003cli\u003eManufactured using ISO 9001 and ISO 13485 certified processes according to 21 CFR 820 medical device current good manufacturing practices (cGMP).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSFM4Insect medium provides excellent growth of many key insect cell lines while requiring minimal adaptation. Additionally, SFM4Insect medium has been successfully tested in a variety of culture systems up to and including high density bioreactors.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17564-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30912.01 \/ 5 L","offer_id":45982125523023,"sku":"SH30912.01","price":1075.0,"currency_code":"ILS","in_stock":true},{"title":"SH30913.02 \/ 1000 mL","offer_id":45982125555791,"sku":"SH30913.02","price":246.0,"currency_code":"ILS","in_stock":true}]},{"product_id":"hyclone-cdm4avian-media-sh31035-01","title":"HyClone™ CDM4Avian media","description":"\u003cp\u003eHyClone™ CDM4Avian cell culture medium is developed for the production of secreted viruses, such as measles, influenza, and Japanese encephalitis (JE); and of non-secreted viruses, such as the modified vaccinia Ankara (MVA) virus, for manufacturing of viral vaccines in avian cell lines.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChemically defined (CD) animal-derived component-free (ADCF) formulation\u003c\/li\u003e\n\u003cli\u003eDesigned to support high peak cell density as well as enhanced viral infectivity and productivity\u003c\/li\u003e\n\u003cli\u003eEconomical, operation-reducing single formulation for cell propagation and viral production\u003c\/li\u003e\n\u003cli\u003eDesigned for small- to large-scale culture applications\u003c\/li\u003e\n\u003cli\u003eAvailable in liquid and powder formulations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith its ADCF formulation, the medium is well-suited for bioprocess applications. CDM4Avian is available in various configurations, ranging from liquid to powder format for small- to large-scale applications \u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17722-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29879073.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L","offer_id":45982125588559,"sku":"SH31035.01","price":1042.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23294-original-png_a66453a8-b3c3-44ab-8d4e-06bd81ca8fe1.png?v=1785958567"},{"product_id":"hyclone-actism-cell-culture-media-sh31038-01","title":"HyClone™ ActiSM™ cell culture media","description":"\u003cp\u003eActiSM™ cell culture media is a chemically defined animal-derived component-free (ADCF) cultured media optimized for high-yield protein production for bioprocessing. This HyClone™ medium is designed for use with ActiPro™ cell culture media .\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChemically defined ADCF formulation optimized for high-yield protein production\u003c\/li\u003e\n\u003cli\u003eDoes not contain hypoxanthine, thymidine, and glycine (HAT supplement)\u003c\/li\u003e\n\u003cli\u003eRecommended for first step when adapting cells cultured in other lean cell culture media\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eActiSM™ medium is intended for use in combination with \u003ca href=\"\/shop\/cell-culture-and-fermentation\/media-and-feeds\/specialty-media\/hyclone-actipro-cell-culture-media-p-06205\"\u003eActiPro™ medium\u003c\/a\u003e and \u003ca href=\"\/shop\/cell-culture-and-fermentation\/reagents-and-supplements\/feed-supplements\/hyclone-cell-boost-7a-supplement-p-06179\"\u003eCell Boost™ 7a\u003c\/a\u003e and \u003ca href=\"\/shop\/cell-culture-and-fermentation\/media-and-feeds\/feed-supplements\/hyclone-cell-boost-7b-supplement-p-06306\"\u003eCell Boost™ 7b\u003c\/a\u003e supplements. This HyClone™ medium is part of the ActiPro™ system of media and supplements designed with adaptation and production in mind. ActiSM™ and the ActiPro™ system are suitable for general biomanufacturing with CHO cell lines such as CHO-GS, CHO-K1, CHO-DG44, and CHO-S. Once your process has been adapted for use with the ActiSM™ medium, we recommend utilizing ActiPro™ medium for production. \u003c\/p\u003e\n\n\u003cp\u003eActiSM™ cell culture medium is available in both powder and liquid formats. ActiSM™ medium does not contain any growth factors (such as insulin), peptides, hydrolysates, phenol red, or 2-mercaptoethanol, ensuring CHO batch-to-batch consistency.  \u003c\/p\u003e\n\n\u003cp\u003eCell culture media formulations and delivery systems can be customized to your specific process requirements or optimized to maximize process yields. Our \u003ca href=\"\/solutions\/bioprocessing\/products-and-solutions\/upstream-bioprocessing\/cell-culture-media-development-service\"\u003e cell culture media and development service\u003c\/a\u003e is available to help you analyze, develop, and optimize your cell culture strategies.\u003c\/p\u003e\n\n\u003cp\u003eIf you have additional questions, \u003ca href=\"\/support\/contact-us\"\u003econtact us\u003c\/a\u003e for scientific or technical support.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17791-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL bottle","offer_id":45982125686863,"sku":"SH31040.02","price":432.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 5 L bottle","offer_id":45982125719631,"sku":"SH31038.01","price":1444.0,"currency_code":"ILS","in_stock":true}]},{"product_id":"hyclone-cdm4ns0-cell-culture-media-sh30578-01","title":"HyClone™ CDM4NS0 cell culture media","description":"\u003cp\u003eRegulatory-friendly medium designed to increase process yields with a variety of NS0 cell clones.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHydrolysate-free and animal-derived component-free formulation.\u003c\/li\u003e\n\u003cli\u003eDeveloped for high cell yield and MAb production.\u003c\/li\u003e\n\u003cli\u003eReady-to-use formulation, requires no cholesterol or GS supplementation.\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation.\u003c\/li\u003e\n\u003cli\u003eDesigned for large-scale culture applications, including perfusion and fed-batch strategies.\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP guidelines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone CDM4NS0 is an animal-derived component-free (ADCF), hydrolysate-free cell culture medium. This regulatory-friendly medium is developed to increase process yields of a variety of NS0 cell clones in the manufacture of monoclonal antibodies (MAbs). CDM4NS0 medium has been formulated to support the needs of NS0 cell clones and as such does not require cholesterol or glutamine synthetase (GS) supplementation. CDM4NS0 medium has been successfully tested in a variety of culture systems, including T-flasks, shaker flasks, and bioreactors using batch and fed-batch strategies. CDM4NS0 is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17557-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30578.01 \/ 5 L bottle","offer_id":45982125785167,"sku":"SH30578.01","price":1595.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23417-original-png_33c8e63b-7071-4251-9d4e-b72de8757b7c.png?v=1785958572"},{"product_id":"hyclone-cell-boost-2-supplement-sh30596-01","title":"HyClone™ Cell Boost™ 2 Supplement","description":"\u003cp\u003eSupplements cell culture with amino acids and glucose and manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern manufacturing processes, Cell Boost™ 2 is chemically defined (CD), animal-derived component-free (ADCF), protein-free, and hydrolysate-free.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid format in addition to a dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell yield in fed-batch cultures by supplementing the cell culture medium to replace nutrients depleted during cell culture. HyClone™ Cell Boost™ 2 Supplement provides amino acids and glucose to support fed batch cultures in research and bioprocessing applications. It is available as a convenient ready-to-use liquid feed solution or as a dry powder feed to be hydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis HyClone™ cell culture supplement has been developed for recombinant protein production with various cell lines including CHO cells and PER.C6 cells.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eSupplement 100 to 200 mL\/L, one or more times, starting during early- to mid-growth phase. This is expected to be day 2 to 4. Start the culture at a reduced volume according to anticipated feed volumes. Continue supplementation daily until the final volume is reached. It is recommended to monitor L- glutamine separately and supplement as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17567-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728531.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982125850703,"sku":"SH30596.01","price":801.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982125883471,"sku":"SH31114.02","price":652.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50054-original-png_f0d56a6d-925a-4106-b08d-55c30b1aca10.png?v=1785958575"},{"product_id":"hyclone-sfm4cho-powder-medium-sh30518-01","title":"HyClone™ SFM4CHO powder medium","description":"\u003cp\u003eSupport growth of CHO cell culture with Cytiva HyClone powdered SFM4CHO media, a cell culture media with animal-derived (AD) components.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProtein-free formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eDesigned for large-scale culture applications, including perfusion and fed-batch strategies\u003c\/li\u003e\n\u003cli\u003eManufactured according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone SFM4CHO is a serum-free and protein-free cell culture medium designed for high performance in a\nvariety of culture applications. The medium supports the dihydrofolate reductase (DHFR) selection\/amplification system and is available with and without L-glutamine to support the glutamine synthetase (GS) gene expression system. SFM4CHO is available in user-friendly packaging in liquid and powder format.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-29298-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30518.01 \/ 5 L","offer_id":45982126440527,"sku":"SH30518.01","price":767.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/69c2a45ee6724ce6b5869640310fc044_c0068a0c-cd59-4882-b332-109d471ad662.png?v=1785956229"},{"product_id":"hyclone-cdm4hek293-media-sh30859-01","title":"HyClone™ CDM4HEK293 media","description":"\u003cp\u003ePromotes adenovirus and recombinant protein production in HEK 293 suspension cell culture.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOptimized for high cell growth and high recombinant protein and vector production with human embryonic kidney (HEK) 293 cells\u003c\/li\u003e\n\u003cli\u003eChemically defined, protein-free and  animal-derived component-free medium available in liquid and powder form\u003c\/li\u003e\n\u003cli\u003eDesigned for small- and large-scale biomanufacturing processes\u003c\/li\u003e\n\u003cli\u003eSupports direct or sequential adaptation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-23608-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L bottle","offer_id":45982126473295,"sku":"SH30859.01","price":1193.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL bottle","offer_id":45982126506063,"sku":"SH30858.02","price":329.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23419-original-png_7bc89614-9ebd-4487-b66d-1ecb963fbac4.png?v=1785958584"},{"product_id":"hyclone-sfm4transfx-293-media-sh30861-01","title":"HyClone™ SFM4Transfx-293 media","description":"\u003cp\u003ePromotes transfection using lipofection, polymer, or similar methods in HEK 293 cell culture.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupports high transfection efficiency.\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation.\u003c\/li\u003e\n\u003cli\u003eAnimal-derived component-free.\u003c\/li\u003e\n\u003cli\u003eManufactured in cGMP (21 CFR 820) compliant and ISO9001 certified facilities.\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein\/vector production.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone SFMTransfx-293 medium is a serum-free and animal-derived component-free medium designed to support the growth of HEK 293 cell cultures and promote transfection using lipofection, polymer, or similar methods. This regulatory-friendly medium was developed to support high transfection efficiency, cell density, and productivity in suspension cultures. \n\nSFM4Transfx-293 medium is available in liquid and powder formats.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17778-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30860.02 \/ 1000 mL bottle","offer_id":45982126604367,"sku":"SH30860.02","price":337.0,"currency_code":"ILS","in_stock":true},{"title":"SH30861.01 \/ 5 L bottle","offer_id":45982126637135,"sku":"SH30861.01","price":1106.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23309-original-png_5680c95b-7f0e-4f0c-b6c9-fc4f1f56efd1.png?v=1785958588"},{"product_id":"hyclone-peak-expression-medium-sh31193-02","title":"HyClone™ peak expression medium","description":"\u003cp\u003eReady-to-use medium supports high cell growth, exceptional transfection efficiency, and robust viral production for adeno-associated virus and lentivirus expressed in human embryonic kidney (HEK293) cell lines. Request a free sample\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReady-to-use medium contains stable L-glutamine and poloxamer 188.\u003c\/li\u003e\n\u003cli\u003eSupports high transfection efficiency.\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and robust virus production.\u003c\/li\u003e\n\u003cli\u003eAllows for direct adaptation.\u003c\/li\u003e\n\u003cli\u003eDesigned for small- to large-scale transfection and production applications.\u003c\/li\u003e\n\u003cli\u003eCompatible with a variety of PEI- and lipid-based transfection reagents.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone™ peak expression medium is an animal-derived component-free (ADCF), chemically defined (CD), hydrolysate-free and regulatory-friendly cell culture medium. The versatility of this medium allows high transfection efficiency, consistent cell growth, high viable cell density, and excellent viral titers across many HEK 293 cell lines. HyClone™ peak expression medium is designed to support outstanding performance in small- and large-scale manufacturing processes and supports seamless transition from growth to production of AAV and lentivirus using standard cell lines and processes. HyClone™ peak expression medium is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/solutions\/cell-therapy\/knowledge-center\/resources\/Recombinant-aav-production-improved-plasmid-transfection\"\u003eLearn more about how HyClone peak expression medium improved the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactors.\u003c\/a\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/solutions\/cell-therapy\/knowledge-center\/resources\/process-development-for-lentiviral-vector-production\"\u003eLearn more about how HyClone peak expression medium has been used for lentiviral production in single-used bioreactors.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/1IVSASSbxESkvmtEnZ4jqQ-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29717925.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL \/ Bottle","offer_id":45982128275535,"sku":"SH31193.02","price":446.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/pFkvcyMB4EGp4Xx5MgSf5Q-original-png_0c7017a8-ec91-4ba8-a797-67ca7a51fc07.png?v=1785958598"},{"product_id":"hyclone-cell-boost-6-supplement-sh30866-01","title":"HyClone™ Cell Boost™ 6 Supplement","description":"\u003cp\u003eSupplements cell culture with lipids, amino acids, vitamins, and growth factors. Manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern manufacturing processes, Cell Boost™ 6 is chemically defined (CD),  animal-derived component-free (ADCF), protein-free, and hydrolysate-free.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid feed solution in addition to a dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell yield in fed-batch cultures by supplementing the cell culture medium to replace nutrients depleted during cell culture. HyClone™ Cell Boost™ 6 Supplement provides lipids, amino acids, vitamins and growth factors to support fed-batch cultures in research and bioprocessing applications. It is available as a convenient ready-to-use liquid feed solution or as a dry powder feed to be rehydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis HyClone™ cell culture supplement has been developed for recombinant protein production with various cell lines including Chinese hamster ovary (CHO) cell line, human embryonic kidney (HEK) 293, NS0, hybridoma, and T cells.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eRecommended supplementation range is between 20 to 200 mL\/L during mid to late growth phase. It is anticipated that this will be day 3 to 4 of the culture. It is suggested that L-glutamine is monitored separately in those cultures where it is present in the culture medium and supplemented as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17570-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728535.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982128308303,"sku":"SH30866.01","price":1059.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982128341071,"sku":"SH31118.02","price":798.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50058-original-png_5b7d0501-af4c-4cdb-856f-690cbd0372e2.png?v=1785958597"},{"product_id":"hyclone-alpha-calf-fraction-media-supplement-u-s-origin-sh30212-03","title":"HyClone™ Alpha Calf Fraction media supplement, U.S. origin","description":"\u003cp\u003ePromote growth with the cost-effective HyClone Alpha Calf Fraction media supplement, designed for antibody production in hybridoma cell cultures.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCost-effective medium supplement optimized for hybridoma cells\u003c\/li\u003e\n\u003cli\u003eSourced in the USA with complete traceability back to the original source.\u003c\/li\u003e\n\u003cli\u003eLow in antibodies and high in growth factors\u003c\/li\u003e\n\u003cli\u003eVirus panel testing according to 9 CFR 113.53\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003ePurchase orders with specific lot requests, quoted reserves and\/or call off orders should be submitted through \u003ca href=\"\/support\/contact-us\"\u003eCustomer Service.\u003c\/a\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eAlpha Calf Fraction is filtered through three sequential 100 nm (0.1 µm) pore size-rated filters. Before dispensing, each lot of serum is pooled using true pool technology to ensure uniformity and consistency between bottles. Produced from  bovine calf serum, using a non-ethanol proprietary process to reduce immunoglobulins and protein to levels very similar to those of Fetal Bovine Serum (FBS). Alpha Calf Fraction typically contains less than 200 μg IgG \/mL.\u003c\/p\u003e\u003cp\u003eAdditional treatments available including heat-inactivation and irradiation. Additional testing, including EMEA-conforming testing, is also available.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17976-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"500 mL","offer_id":45982134108239,"sku":"SH30212.03","price":663.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23398-original-png_5da8b3d2-f5e1-4ed7-a438-10717ecfed17.png?v=1785958659"},{"product_id":"hyclone-cell-boost-3-supplement-sh31115-02","title":"HyClone™ Cell Boost™ 3 Supplement","description":"\u003cp\u003eSupplements cell culture with amino acids, vitamins, glucose, and trace elements and manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern manufacturing processes, Cell Boost™ 3 is chemically defined (CD), animal-derived component-free (ADCF), protein-free, and hydrolysate-free.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid solution in addition to a dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell yield in fed-batch cultures by supplementing the cell culture medium to replace nutrients depleted during cell culture. HyClone™ Cell Boost™ 3 Supplement provides amino acids, vitamins, glucose, and trace elements to support fed-batch cultures in research and bioprocessing applications. It is available as a convenient ready-to-use liquid feed solution or as a dry powder feed to be hydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis HyClone™ cell culture supplement has been developed for recombinant protein production with various cell lines including hybridoma and myeloma cell lines.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eSupplement 20 to 200 mL\/L one or more times, starting during mid to late growth phase. This is expected to be day 3 to 4. Start the culture at a reduced volume according to anticipated feed volumes. Continue supplementation daily until the final volume is reached. It is recommended to monitor L- glutamine separately and supplement as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17568-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728532.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982134337615,"sku":"SH30825.01","price":755.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982134370383,"sku":"SH31115.02","price":655.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50055-original-png_6f648e0c-6af2-4c09-b902-5dfc2424b2b4.png?v=1785958664"},{"product_id":"hyclone-cell-boost-5-supplement-sh31117-02","title":"HyClone™ Cell Boost™ 5 Supplement","description":"\u003cp\u003eSupplements cell culture with lipids, amino acids, vitamins, and growth factors. Manufactured to meet cGMP manufacturing standards and QC specifications.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned to support modern manufacturing processes, Cell Boost™ 5 is chemically defined (CD), animal-derived component-free (ADCF), protein-free, and hydrolysate-free.\u003c\/li\u003e\n\u003cli\u003eFor convenience, this cell culture supplement is available as a ready-to-use liquid feed solution in addition to a dry powder format.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eImprove productivity and cell yield in fed-batch cultures by supplementing the cell culture medium to replace nutrients depleted during cell culture. HyClone™ Cell Boost™ 5 Supplement provides lipids, amino acids, vitamins, and growth factors to support fed-batch cultures in research and bioprocessing applications. It is available as a convenient ready-to-use liquid feed solution or as a dry powder feed to be hydrated before use.\u003c\/p\u003e\n\n\u003cp\u003eFed-batch applications\u003c\/p\u003e\n\n\u003cp\u003eThis HyClone™ cell culture supplement has been developed for recombinant protein production with various cell lines including Chinese hamster ovary (CHO) cell line, human embryonic kidney (HEK) 293, NS0, and hybridoma cells.\u003c\/p\u003e\n\n\u003cp\u003eGeneral culture recommendations\u003c\/p\u003e\n\n\u003cp\u003eRecommended supplementation range is between 20 to 200 mL\/L during mid to late growth phase. It is anticipated that this will be day 3 to 4 of the culture. It is suggested that L-glutamine is monitored separately in those cultures where it is present in the culture medium and supplemented as needed.\u003c\/p\u003e\n\n\u003cp\u003eDry powdered medium milling equivalency study\u003c\/p\u003e\n\n\u003cp\u003eThis study \u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/media-powder-milling-study\"\u003ecompares pin milling of powdered HyClone™ cell culture media and supplements\u003c\/a\u003e at two manufacturing sites. Detailed physical, chemical, and biological data, including cell growth, are provided.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17565-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29728534.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"100 g","offer_id":45982134435919,"sku":"SH30865.01","price":1073.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982134468687,"sku":"SH31117.02","price":902.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-50057-original-png_540f86ac-e467-4971-8fcb-9f6d78302685.png?v=1785958667"},{"product_id":"hyclone-hycell-transfx-h-transfection-media-sh30944-01","title":"HyClone™ HyCell TransFx-H transfection media","description":"\u003cp\u003eSupports transient transfection, growth, and expression of a variety of recombinant proteins in HEK 293 cells.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHydrolysate-free and ADCF formulation\u003c\/li\u003e\n\u003cli\u003eSupports high transfection efficiency\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eDesigned for micro- to large-scale transfection and production applications\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone HyCell TransFx-H is an animal-derived componentfree (ADCF), hydrolysate-free, and regulatory-friendly cell culture medium. The versatility of this medium allows quick adaptation and supports exceptional transfection, high viable cell density, and high productivity across a variety of human embryonic kidney (HEK) 293 cell lines. HyCell TransFx-H is available in liquid and powder formats in userfriendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17556-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"5 L","offer_id":45982134501455,"sku":"SH30944.01","price":1370.0,"currency_code":"ILS","in_stock":true},{"title":"1000 mL","offer_id":45982134534223,"sku":"SH30939.02","price":389.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23302-original-png.png?v=1782740614"},{"product_id":"hyclone-sfm4hek293-media-sh30521-02","title":"HyClone™ SFM4HEK293 media","description":"\u003cp\u003ePromotes adenovirus and recombinant protein production in HEK 293 cell culture.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOptimized for high cell growth and high recombinant protein and vector production with human embryonic kidney (HEK) 293 cells\u003c\/li\u003e\n\u003cli\u003eProtein-free and  animal-derived component-free medium available in liquid and powder form\u003c\/li\u003e\n\u003cli\u003eDesigned for small- and large-scale biomanufacturing processes\u003c\/li\u003e\n\u003cli\u003eManufactured in cGMP (21 CFR 820) compliant and ISO9001 certified facilities\u003c\/li\u003e\n\u003cli\u003eSupports direct or sequential adaptation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17614-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1000 mL bottle","offer_id":45982134632527,"sku":"SH30521.02","price":327.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23314-original-png_773443dd-e9e8-46c8-bb32-4e934fdaefb1.png?v=1785958672"},{"product_id":"hyclone-hycell-transfx-c-transfection-media-sh30941-02","title":"HyClone™ HyCell TransFx-C transfection media","description":"\u003cp\u003eSupports transient transfection, growth, and expression of a variety of recombinant proteins in CHO cells.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eADCF and hydrolysate-free formulation\u003c\/li\u003e\n\u003cli\u003eSupports high transfection efficiency\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eDesigned for micro- to large-scale transfection and production applications\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone HyCell TransFx-C is an animal-derived component-free (ADCF), hydrolysate-free, and regulatory-friendly cell culture medium. The versatility of this medium allows quick adaptation and supports exceptional transfection, high viable cell density, and high productivity across a variety of Chinese hamster ovary (CHO) cell lines. HyCell TransFx-C is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17555-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30941.02 \/ Liquid \/ 1 L bottle","offer_id":45982134796367,"sku":"SH30941.02","price":385.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23303-original-png_d70b2f6e-8faf-411a-bd2b-64da8d2250d1.png?v=1785958675"},{"product_id":"hyclone-sfm4cho-cell-culture-media-sh30549-02","title":"HyClone™ SFM4CHO cell culture media","description":"\u003cp\u003eSerum-free, protein-free media for use with CHO cells.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProtein-free formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eDesigned for large-scale culture applications, including perfusion and fed-batch strategies\u003c\/li\u003e\n\u003cli\u003eManufactured according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone SFM4CHO supports the dihydrofolate reductase (DHFR) selection\/amplification system and is available with and without L-glutamine to support the glutamine synthetase (GS) gene expression system. SFM4CHO is available in user-friendly packaging in liquid and powder format.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-29298-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30548.02 \/ 1000 mL","offer_id":45982134927439,"sku":"SH30548.02","price":288.0,"currency_code":"ILS","in_stock":true},{"title":"SH30549.02 \/ 1000 mL","offer_id":45982134960207,"sku":"SH30549.02","price":285.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23316-original-png_c0bf920d-5cb8-4a36-aac1-3501b2e0b9f5.png?v=1785958680"},{"product_id":"hyclone-adcf-mab-media-sh30349-02","title":"HyClone™ ADCF-mAb media","description":"\u003cp\u003eProtein-free and animal-derived component-free medium\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAnimal-derived component-free (ADCF) formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and monoclonal antibody (MAb) production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eComponent traceability\u003c\/li\u003e\n\u003cli\u003eManufactured in cGMP (21 CFR 820) compliant and ISO9001 certified facilities\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eADCF-mAb liquid medium contains poloxamer 188 and L-glutamine, and does not contain phenol red. Liquid medium is also available without L-glutamine to support the glutamine synthetase (GS) gene expression system. ADCF‑mAb powder medium does not contain poloxamer 188, L-glutamine, phenol red, or sodium bicarbonate. ADCF-mAb is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\u003cp\u003eHyClone ADCF-mAb cell culture medium is protein-free and contains no animal-derived components. This regulatory-friendly medium is developed to increase the process yields for the manufacture of antibodies and antibody fragments for therapeutic use in a variety of engineered hybridoma and myeloma cell lines.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17559-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL bottle","offer_id":45982135025743,"sku":"SH30349.02","price":283.0,"currency_code":"ILS","in_stock":true},{"title":"Liquid \/ Six 1000 mL bottles","offer_id":45982135058511,"sku":"SH30349.LS","price":1547.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23297-original-png_4f6aa814-7e65-4265-b7a8-a68f60edac21.png?v=1785958680"},{"product_id":"hyclone-cdm4cho-cell-culture-media-sh30556-01","title":"HyClone™ CDM4CHO cell culture media","description":"\u003cp\u003eA chemically defined, protein-free ADCF cell culture medium.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChemically defined and animal-derived component-free formulation\u003c\/li\u003e\n\u003cli\u003eDesigned for high cell yield and recombinant protein production\u003c\/li\u003e\n\u003cli\u003eAllows for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eDesigned for large-scale culture applications, including perfusion and fed-batch strategies\u003c\/li\u003e\n\u003cli\u003eManufactured from traceable components and according to cGMP guidelines\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone CDM4CHO is a protein-free and animal-derived component-free (ADCF) cell culture medium. This regulatory-friendly medium is developed to increase process yields for the industrial manufacture of recombinant proteins using a variety of CHO cell clones. CDM4CHO medium has been successfully tested in a variety of culture systems, including T-flasks, shaker flasks, and bioreactors including fed-batch and perfusion culturing. CDM4CHO medium is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17785-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Liquid \/ 1000 mL","offer_id":45982135517263,"sku":"SH30558.02","price":327.0,"currency_code":"ILS","in_stock":true},{"title":"Liquid \/ 1000 mL bottle","offer_id":45982135550031,"sku":"SH30557.02","price":337.0,"currency_code":"ILS","in_stock":true},{"title":"Powder \/ 5 L","offer_id":45982135582799,"sku":"SH30556.01","price":991.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-26598-original-png_db54dca1-1c7a-468a-a83d-bb84c07ddfe7.png?v=1785958689"},{"product_id":"hyclone-sfm4mab-media-sh30513-02","title":"HyClone™ SFM4MAb media","description":"\u003cp\u003eIncrease process yields for manufacturing of human and humanized recombinant antibodies.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDesigned for high cell yield and antibody production\u003c\/li\u003e\n\u003cli\u003eComplexed lipids for enhanced stability\u003c\/li\u003e\n\u003cli\u003eAllow for direct or sequential adaptation\u003c\/li\u003e\n\u003cli\u003eOptimized for protein A, protein G, and other purification matrices\u003c\/li\u003e\n\u003cli\u003eManufactured in cGMP (21 CFR 820) compliant and ISO9001 certified facilities\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSFM4MAb is a low protein formulation and is optimized for downstream purification using protein A, protein G, and other matrices to facilitate product recovery. The medium is formulated using our proprietary lipid and phospholipid complexing process for enhanced stability and growth promotion of various cell types. SFM4MAb is available in liquid and powder formats in user-friendly packaging.\u003c\/p\u003e\u003cp\u003eHyClone SFM4MAb medium is developed to increase the process yields for the industrial manufacture of recombinant antibodies and antibody fragments for therapeutic use. SFM4MAb has been optimized in a variety of engineered hybridoma and recombinant myeloma cell lines.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17662-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH30513.02 \/ 1000 mL","offer_id":45982135681103,"sku":"SH30513.02","price":274.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-23312-original-png_2bb67ba9-122b-46b8-ab54-3fa36b2107e1.png?v=1785958693"},{"product_id":"hyclone-vaccinexpress-cell-culture-media-sh31126-01","title":"HyClone™ VaccineXpress cell culture media","description":"\u003cp\u003eHyClone VaccineXpress cell culture medium is designed and developed for high‑density growth and maintenance of kidney‑derived cell lines (e.g., Vero cells) for viral vaccine development. VaccineXpress medium is well suited for use in multi-well plates and large‑scale manufacturing using microcarriers in WAVE Bioreactor or Xcellerex bioreactors.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSerum-free animal-derived component-free formulation\u003c\/li\u003e\n\u003cli\u003eSupports direct or sequential adaptation, cell growth and virus propagation\u003c\/li\u003e\n\u003cli\u003eDesigned to support high peak cell density, viral infectivity, and productivity\u003c\/li\u003e\n\u003cli\u003eFor use with multiple viral applications (i.e., influenza, rotavirus, RSV, Dengue, Zika)\u003c\/li\u003e\n\u003cli\u003eDesigned for small- to large-scale cell culture applications with use of microcarriers\u003c\/li\u003e\n\u003cli\u003eAvailable in liquid and powder formulations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHyClone VaccineXpress medium has been qualified to grow attachment‑dependent Vero cells with microcarriers for producing viral vaccines. The lack of both serum and animal‑derived components in the medium reduces variability and enhances scalability and ease of purifying recombinant proteins and viruses in bioprocess applications. VaccineXpress is formulated without L‑glutamine for extended shelf life.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/Scalable-ADCF-virus-production\"\u003eLearn about Scalable ADCF virus production using HyClone VaccineXpress medium.\u003c\/a\u003e\n\u003c\/p\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-25818-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29879075.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"SH31126.01 \/ 1000 mL","offer_id":45982136369231,"sku":"SH31126.01","price":465.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-24199-original-png_be7a460f-3d1d-456d-8790-244194a6a86d.png?v=1785958701"},{"product_id":"cd34-hsc-lnp-kits-29874065","title":"CD34+ HSC LNP kits","description":"\u003cp\u003eThe CD34+ HSC LNP kit is an LNP reagent mix optimized for the delivery of mRNA or Cas9 mRNA\/sgRNA into CD34+ HSCs. This reagent enables researchers to establish a clinically relevant and scalable method at the discovery and preclinical scale for ex vivo gene delivery and editing. CD34+ HSC LNP kit offers the following benefits:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOptimized LNP formulation: Deliver RNA with high transfection efficiency by using an optimized proprietary LNP formulation*\u003c\/li\u003e\n\u003cli\u003eHigh knockout efficiency: Achieve dose-dependent high efficiency gene knockdown and protein expression.\u003c\/li\u003e\n\u003cli\u003eHigh cell yield and differentiation potential: Maintain high cell viability, yield, and differentiation potential post-editing.\u003c\/li\u003e\n\u003cli\u003eScale from discovery to preclinical: Scale up your ex vivo cell therapy research from discovery to preclinical using the NanoAssemblr™ platform.\u003c\/li\u003e\n\u003cli\u003eValidated workflow: Optimized and validated with the CD34+ HSC cell manufacturing workflow.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*LNP composition in this research-use-only kit include ionizable lipid excipients that can be licensed for future clinical evaluation.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eEasily integrated into standard CD34+ HSC cell culture protocols\u003c\/p\u003e\n\n\u003cp\u003eThe CD34+ HSC LNP kits can be easily integrated into a CD34+ HSC workflow for both mRNA-based gene expression and CRISPR\/Cas gene editing applications. A general workflow is outlined below.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/TAhrIm8PQCOva0Duhg1BJg-original-png?v=59a646df\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eSchematic diagram of the LNP treatment and HSC cell culture workflow. LNP production may be decoupled from the cell culture workflow, allowing greater flexibility and simplicity of workflow.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eDose-dependent gene knockout of CD45\u003c\/p\u003e\n\n\u003cp\u003eAchieve dose-dependent highly efficient genome editing of CD34+ HSCs sourced from human cord blood and human mobilized peripheral blood using the CD34+ HSC LNP kit, 100 µL on the NanoAssemblr™ Spark™ system, and CD34+ HSC LNP kit, 2 mL on the NanoAssemblr™ Ignite™ instrument.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/rR_pz-gPR2689T5cqoNVtA-original-png?v=999c0561\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eA) CD45 dose response of CRISPR-Cas9 mRNA and sgRNA LNPs produced on the NanoAssmblr™ Spark™ instrument. B) Corresponding cell viability. C) Representative images of untreated and CRISPR RNA-LNP treated CFU plates. D) Normalized erythroid and myeloid colony yields of untreated (UT), empty LNP treated, and CRISPR RNA-LNP treated samples.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eCell proliferation and viability following LNP treatment\u003c\/p\u003e\n\n\u003cp\u003eLNP-treated HSCs show high cell proliferation and viability.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/M6ThkxmcRF-I_nf4eRxFgQ-original-png?v=bbd6fe79\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eA) Cell proliferation and B) viability monitored for over 1 week after LNP-mediated CD45 targeted CRISPR RNA-LNP treated gene editing of HSCs. C) LNP-mediated gene editing compared across n = 2 donors using flow cytometry via CD45 surface expression analysis and D) corresponding histogram.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eHSC cryopreservation and freeze-thawing post-LNP treatment\u003c\/p\u003e\n\n\u003cp\u003eCryopreservation of LNP-treated HSCs showed high cell viability and yield. Furthermore, cells retained their engraftable HSC phenotype distribution while maintaining CD45 knockout efficiency.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/MMoVTqzxSAiQNaM1uJc4mw-original-png?v=e83611fe\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eCryopreservation of HSCs post-LNP-mediated CRISPR Cas9 gene editing. A) Schematic diagram of the freeze-thaw (F\/T) cycles of HSCs. B) Post-thaw, or non-frozen long-term repopulating HSC phenotype levels, at either 24h or 48h post-LNP treatment freeze time points. C) Cell viability and live cell recovery post 24h-LNP treatment F\/T cycle. D) CD45 knockout efficiency observed in freeze-thawed and fresh LNP-treated HSCs in total live cells and engraftable phenotype (CD34+ CD38- CD90+ CD133+).\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eScale-up of cell culture and RNA-LNP production\u003c\/p\u003e\n\n\u003cp\u003eThe CD34+ HSC LNP kits are available on the NanoAssemblr™ Spark™ and NanoAssemblr™ Ignite™ instruments. Reagents are also available for scaling process development and GMP manufacturing through BioPharma Services.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/YxI-O2j6QoqDTTfxyWbMOQ-original-png?v=1499b484\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eThe CD34+ HSC LNP kits combined with the NanoAssemblr™ platform enables robust and equivalent performance on both the Spark™ and Ignite™ instruments and offers seamless scalability from discovery to preclinical studies.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/d8kdlt2yRkOBImxBNZm1nQ-original-png?v=b1b2f73a\" style=\"max-width: 1250px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eA) CD45 knockout and B) CD33 knockout of the total live cell population, as well as C) corresponding cell viability. A-C includes \u0026gt;20 unique experiments with \u0026gt;4 unique donors. D) Untreated, empty-LNP, and CRISPR-Cas9 RNA-loaded LNP treated HSCs were assessed for proliferation using an automated cell counter. E) Untreated, empty-LNP and CRISPR-Cas9 RNA-loaded LNP treated HSCs were assessed for clonogenicity using an automated CFU counter, 5 independent experiments with Spark™ and 2 independent experiments with the Ignite™ instrument.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eKit components\u003c\/p\u003e\n\n\u003cdiv class=\"table-responsive\"\u003e\n\u003ctable class=\"table table-bordered\"\u003e\n\t\u003cthead\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003e \u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eCD34+ HSC LNP kit, 100 µL, (Part No. 1003000)\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eCD34+ HSC LNP kit, 100 µL with cartridges, (Part No. 1004000)\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eCD34+ HSC LNP kit, 2 mL, (Part No. 105000)\u003c\/th\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/thead\u003e\n\t\u003ctbody\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eLipid mix\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e2 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eFormulation buffer type 1\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e400 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e400 µL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e1.6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eDilution buffer type 1\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e1.5 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e1.5 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 mL (10X)\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eCryopreservation buffer type 2\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eApolipoprotein-E3 (ApoE3)\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 µg\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 µg\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e500 do\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eSpark™ Cartridges\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e5\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e-\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/01002515_fr.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Ignite","offer_id":45982289657935,"sku":"1005000","price":806.0,"currency_code":"ILS","in_stock":true},{"title":"Spark (29874065)","offer_id":45982289690703,"sku":"29874065","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Spark (1003000)","offer_id":45982289723471,"sku":"1003000","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/bIJ4A6eTVu4DK6eUe68ag-original-png_2a5b2683-bdbb-4dc1-bea5-252f0caa8b04.png?v=1785959954"},{"product_id":"xuri-il-21-growth-factor-29112119","title":"Xuri™ IL-21 growth factor","description":"\u003cp\u003eCell growth factor Xuri IL-21 regulates human natural killer (NK) and cytotoxic T cells. It follows USP for cell therapy ancillary material.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMinimized process development time.\u003c\/li\u003e\n\u003cli\u003eImproved scale-out capacity.\u003c\/li\u003e\n\u003cli\u003eReproducible performance without revalidation of each lot.\u003c\/li\u003e\n\u003cli\u003eDedicated cell therapy ancillary product following USP  for ex vivo cultivation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRapid and dependable process development for cell therapy manufacturing\u003c\/p\u003e\u003cp\u003eEach lot of Xuri IL-21 includes clear information on biological activity to improve control over cultivation variability. This information enables standardization of the process to deliver reproducible cell expansion without the need for revalidation of each new lot.\u003c\/p\u003e\u003cp\u003eUSP \u0026lt;1043\u0026gt; compliance\u003c\/p\u003e\u003cp\u003eA smooth submission process is key when dealing with cell therapy regulatory requirements. To help users assess and document production processes, Cytiva supplies Xuri IL-21 with a comprehensive documentation support package that meets USP \u0026lt;1043\u0026gt; ‘ancillary materials for cell, gene, and tissue-engineered products’, within the responsibilities applicable to a supplier.\u003c\/p\u003e\u003cp\u003eEnd user responsibility\u003c\/p\u003e\u003cp\u003eOther aspects of USP \u0026lt;1043\u0026gt; will be the responsibility of the end user to assess. Cytiva cannot fulfill USP \u0026lt;1043\u0026gt; in regard to application and therapy specific aspects (e.g., use in finished therapeutic, assessment of removal from a finished therapeutic and possible biocompatibility, cytotoxicity or adventitious agent testing). No human components are included in the product.\u003c\/p\u003e\u003cp\u003eLong-standing experience\u003c\/p\u003e\u003cp\u003eCytiva, a well-established supplier to the clinical and pharmaceutical market worldwide, now brings its long-standing experience in regulatory requirements to the field of cell therapy manufacturing.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17164-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29154916.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Default Title","offer_id":45982291001423,"sku":"29112119","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-26270-original-png_cf2cb38a-0f98-4813-bff2-f79810d458fa.png?v=1785959990"},{"product_id":"xuri-il-15-growth-factor-29112116","title":"Xuri™ IL-15 growth factor","description":"\u003cp\u003eRegulates activation and proliferation of human blood lymphocytes, following USP for cell therapy ancillary material.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMinimized process development time.\u003c\/li\u003e\n\u003cli\u003eImproved scale-out capacity.\u003c\/li\u003e\n\u003cli\u003eReproducible performance without revalidation of each lot.\u003c\/li\u003e\n\u003cli\u003eDedicated cell therapy ancillary product following USP  for ex vivo cultivation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRapid and dependable process development for cell therapy manufacturing\u003c\/p\u003e\u003cp\u003eEach lot of Xuri IL-15 includes clear information on biological activity to improve control over cultivation variability. This information enables standardization of the process to deliver reproducible cell expansion without the need for revalidation of each new lot.\u003c\/p\u003e\u003cp\u003eUSP \u0026lt;1043\u0026gt; compliance\u003c\/p\u003e\u003cp\u003eA smooth submission process is key when dealing with cell therapy regulatory requirements. To help users assess and document production processes, Cytiva supplies Xuri IL-15 products with a comprehensive documentation support package that meets USP \u0026lt;1043\u0026gt; ‘ancillary materials for cell, gene, and tissue-engineered products’, within the responsibilities applicable to a supplier.\u003c\/p\u003e\u003cp\u003eEnd user responsibility\u003c\/p\u003e\u003cp\u003eOther aspects of USP \u0026lt;1043\u0026gt; will be the responsibility of the end user to assess. Cytiva cannot fulfill USP \u0026lt;1043\u0026gt; in regard to application and therapy specific aspects (e.g., use in finished therapeutic, assessment of removal from a finished therapeutic and possible biocompatibility, cytotoxicity or adventitious agent testing). No human components are included in the product.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-17164-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29154914.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Default Title","offer_id":45982291165263,"sku":"29112116","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-26269-original-png_6a5ff9fc-2330-442e-a46a-0da6362149a2.png?v=1785959996"},{"product_id":"rna-delivery-lnp-kit-1002569","title":"RNA delivery LNP kit","description":"\u003cp\u003eThe RNA delivery LNP kit for the NanoAssemblr™ Ignite™ and Ignite+™ systems offers ready–to–use ionizable lipid mix and buffers to fast-track payload screening and RNA drug delivery validation, progressing lead candidates quickly through preclinical studies accelerating clinical evaluation.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePreoptimized ionizable lipid mix for RNA-LNP delivery to accelerate lead candidate selection\u003c\/li\u003e\n\u003cli\u003eRapid and easy prep of high-quality, stable LNPs using prepared reagents and protocols\u003c\/li\u003e\n\u003cli\u003eEasily scalable on the NanoAssemblr™ system platform\u003c\/li\u003e\n\u003cli\u003eIncludes in vitro protein expression and in vivo immunogenicity proof-of-concept data for mRNA vaccine applications, validated for reproducible, high-quality LNP production and stability, up to clinical and commercial nanomedicine manufacturing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*LNP composition in this research-use-only kit includes an ionizable lipid excipient that can be licensed for future clinical evaluation.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eStreamline payload screening and lead candidate optimization\u003c\/p\u003e\n\n\u003cp\u003eOff-the-shelf reagent kits offer easy screening of RNA payloads and lead candidate optimization for physicochemical attributes and potency to fast-track lead candidate selection for RNA drug delivery.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/7VmaLhmKSXOY1rW62o4UJw-original-png?v=a458877c\" style=\"max-width: 700px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eGraphs above show (left) the LNP size and polydispersity (PDI), and (right) the encapsulation efficiency of LNPs, prepared using the RNA delivery LNP kit with both mRNA and self-amplifying RNA encoding for different antigens.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/xeBJC5elSDq2dJLAF_ShFA-original?v=04fc1acf\" style=\"max-width: 600px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eLNPs were prepared using the RNA delivery LNP kit and mRNA encoding for haemagglutinin (HA), a surface protein on the H1N1 virus. LNPs were used to immunize BALB\/c mice with a primary and booster dose of 2 μg RNA on days 0 and 28 of the immunization schedule. The immunogenicity of LNPs is shown in the graph above, showing the HA inhibition titers using serum sampled on days 21 and 42.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eQuality RNA-LNP formulations\u003c\/p\u003e\n\n\u003cp\u003eThe RNA delivery LNP kit consistently produces quality LNPs that are highly effective in protecting encapsulated nucleic acids, maintaining critical quality attributes (CQAs) and potency over time.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/_imLlUV-RWOYqIHkMliSgQ-original?v=488c4998\" style=\"max-width: 850px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eStorage stability and CQA consistency of LNPs produced with the RNA delivery LNP kit, prepared with cryopreservation buffer, over 1 week of storage under refrigerated conditions and 6 weeks of storage at -80°C.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/8xEaYUR8TkK9ixYvNxRLsw-original-png?v=20640fd0\" style=\"max-width: 850px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eIn vitro\u003c\/em\u003e potency of lead candidate LNPs encapsulating (A) eGFP mRNA or (B) eGFP saRNA in HEK-293 cells over 1 week of storage under refrigerated conditions and 6 weeks of storage at -80°C.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eScalable NxGen™ technology\u003c\/p\u003e\n\n\u003cp\u003eGenomic medicine success starts at the discovery phase, by validating RNA drug delivery with ionizable lipid compositions and LNP technologies at a small scale. This allows for consistent LNP formulation using the NanoAssemblr™ NxGen™ platform for clinical evaluation and commercial production.\u003c\/p\u003e\n\n\u003cp\u003e\u003cimg alt=\"\" class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/AeegOA3SRmiUMlGmnBZBUA-original-png?v=6ac90a53\" style=\"max-width: 700px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003eImmunogenicity of saRNA-LNPs prepared using NanoAssemblr™ NxGen™ technology at different scales, showing the log-transformed SARS-CoV-2 spike protein specific IgG titers in serum of BALB\/c mice treated with lead candidate saRNA-LNPs.\u003c\/p\u003e\n\n\u003cp class=\"-font--plus-1 -padding--title-md\"\u003eKit components\u003c\/p\u003e\n\n\u003cdiv class=\"table-responsive\"\u003e\n\u003ctable class=\"table table-bordered\"\u003e\n\t\u003cthead\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003e \u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eRNA delivery LNP kit, 3 mL\u003cbr\u003e\n\t\t\t1002569\u003c\/th\u003e\n\t\t\t\u003cth class=\"-font--body\"\u003eRNA delivery LNP kit, 6 mL\u003cbr\u003e\n\t\t\t1002471\u003c\/th\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/thead\u003e\n\t\u003ctbody\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eLipid mix\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e3 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eFormulation buffer\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e6 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eDilution buffer\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e100 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\t\u003ctr\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003eCryopreservation buffer\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e12 mL\u003c\/td\u003e\n\t\t\t\u003ctd class=\"-font--body\"\u003e12 mL\u003c\/td\u003e\n\t\t\u003c\/tr\u003e\n\t\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29798795_fr.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Ignite, Ignite+ (1002569)","offer_id":45982350049359,"sku":"1002569","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ignite, Ignite+ (1002471)","offer_id":45982350082127,"sku":"1002471","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/E5vcyaJGTdKW1hx-AhUyzA-original-png_8c5166a2-9771-44da-b47d-6c3d10d85aaa.png?v=1785960393"},{"product_id":"ficoll-paque-premium-density-gradient-media-17544602","title":"Ficoll-Paque™ PREMIUM density gradient media","description":"\u003cp\u003eReady-to-use sterile density gradient media designed for the preparation of mononuclear cells from peripheral blood, bone marrow and cord blood.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eManufactured under a Quality Management System certified to ISO 13485.\u003c\/li\u003e\n\u003cli\u003eLow levels of endotoxin (\u0026lt; 0.12 EU\/mL) secured and tested.\u003c\/li\u003e\n\u003cli\u003eCytotoxicity grade 0.\u003c\/li\u003e\n\u003cli\u003eChoice of densities: 1.077, 1.084, and 1.073 g\/mL.\u003c\/li\u003e\n\u003cli\u003eA Regulatory Support File (RSF) is available for Ficoll-Paque PREMIUM products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFicoll-Paque PREMIUM vs Ficoll-Paque PLUS\u003c\/p\u003e\n\n\u003cp\u003eAll Ficoll-Paque PREMIUM products differ from Ficoll-Paque PLUS in that they are manufactured under a Quality Management System certified to ISO 13485.\u003c\/p\u003e\n\n\u003cp\u003eHow it's used\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003eFicoll-Paque PREMIUM: Optimized for the isolation of mononuclear cells from human peripheral blood, bone marrow, and umbilical cord blood.\u003c\/li\u003e\n\t\u003cli\u003eFicoll-Paque PREMIUM 1.084: Can be used for isolating a broad range of human mononuclear cells including those of a higher density and for separating blood cells from mice or rats.\u003c\/li\u003e\n\t\u003cli\u003eFicoll-Paque PREMIUM 1.073: Can be used when isolating lower-density human mononuclear cells (e.g. mesenchymal stromal cells or monocytes).\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-46695-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/28403956.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1.074 g\/ml \/ 6 x 100 mL","offer_id":45982361681999,"sku":"17544652","price":1558.0,"currency_code":"ILS","in_stock":true},{"title":"1.078 g\/ml \/ 6 x 100 mL","offer_id":45982361714767,"sku":"17544202","price":951.0,"currency_code":"ILS","in_stock":true},{"title":"1.078 g\/ml \/ 6 × 500 mL","offer_id":45982361747535,"sku":"17544203","price":4228.0,"currency_code":"ILS","in_stock":true},{"title":"1.085 g\/ml \/ 6 x 100 mL","offer_id":45982361780303,"sku":"17544602","price":1558.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-4572-original-png_e80bdc9d-cec3-4d2a-beab-37a50bb3530d.png?v=1785960522"},{"product_id":"ficoll-paque-plus-density-gradient-media-17144003","title":"Ficoll-Paque™ PLUS density gradient media","description":"\u003cp\u003eA recognized worldwide standard sterile medium designed for isolating human lymphocytes for in vitro studies.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReady-to-use sterile density gradient medium for high-yield isolation of human lymphocytes from peripheral blood.\u003c\/li\u003e\n\u003cli\u003eMaintains viability and representative distribution of B and T cells.\u003c\/li\u003e\n\u003cli\u003eLow levels of endotoxin (\u0026lt;0.12 EU\/mL).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eRecognized standard\u003c\/p\u003e\n\n\u003cp\u003eFicoll-Paque™ PLUS (density 1.077 g\/mL) media is a recognized standard in laboratories worldwide for the isolation of mononuclear cells for analytical research studies.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-14502-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/71716700.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"6 x 100 mL","offer_id":45982362697807,"sku":"17144002","price":1159.0,"currency_code":"ILS","in_stock":true},{"title":"6 × 500 mL","offer_id":45982362730575,"sku":"17144003","price":3106.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-4040-original-png_9fee945e-7ece-4ca3-b1ce-20ddf6ebcd5c.png?v=1785960540"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/collections\/digi-26598-original-png_db54dca1-1c7a-468a-a83d-bb84c07ddfe7.png?v=1790861659","url":"https:\/\/www.danyel.co.il\/collections\/bioprocess-media-and-cell-therapy-reagents.oembed","provider":"danyel biotech","version":"1.0","type":"link"}